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Table 5 Short-term postoperative outcome, 90-day graft and patient survival of IRI and non-IRI patients

From: Procalcitonin in early allograft dysfunction after orthotopic liver transplantation: a retrospective single centre study

 

Non-IRI (n = 64)

IRI (n = 46)

p-value

IRI and PCT > 15 mcg/l (n = 27)

p-value (vs. no IRI)

IRI and PCT < 15 mcg/l (n = 19)

p-value (vs. no IRI)

Severity of IRI (peak ALT/AST)*

681 (338–1250)

4563 (3108–7959)

< 0.001

4940 (3324–7607)

< 0.001

3721 (2960–9180)

< 0.001

Overall major complication**

34 (53.1%)

31 (67.4%)

0.133

18 (66.7%)

0.233

13 (68.4%)

0.237

Reoperation

19 (29.7%)

25 (54.3%)

0.009

12 (44.4%)

0.175

13 (68.4%)

0.002

Postoperative RRT

30 (46.9%)

28 (60.9%)

0.147

17 (63.0%)

0.161

11 (57.9%)

0.399

Arterial complications

2 (3.1%)

5 (10.9%)

0.127

2 (7.4%)

0.579

3 (15.8%)

0.076

 Hepatic artery thrombosis

1 (1.6%)

2 (4.3%)

0.57

1 (3.7%)

0.508

1 (5.3%)

0.408

Biliary complications

9 (14.1%)

8 (17.4%)

0.634

3 (11.1%)

1.0

5 (26.3%)

0.293

ICU length of stay (days)

3 (2–5)

4 (2–8)

0.005

4 (2–6)

0.065

5 (3–14)

0.006

Hospital length of stay (days)

17 (13–22)

17 (13–24)

0.684

16 (13–18)

0.889

21 (11–35)

0.368

90-day outcome

90-day graft survival

60 (93.8%)

37 (80.4%)

0.033

26 (96.3%)

1.0

11 (57.9%)

0.001

90-day patient survival

60 (93.8%)

39 (84.8%)

0.196

26 (96.3%)

1.0

13 (68.4%)

0.008

  1. Continous variables are displayed as median and interquartile range
  2. EAD earyl allograft dysfunction, IRI ischemia-reperfusion injury, CRP C-reactive protein, PCT procalcitonin, ALT alanine aminotransferase, AST aspartate aminotransferase, RRT renal replacement therapy
  3. *Peak ALT/AST first 2 days
  4. **Clavien-Dindo-stage ≥ 3B requiring intervention under general anesthesia, life-threatening complication requiring IC/ICU management, death of the patient