Table 4 Distribution of alleles and genotypes for PNPLA3 rs738409 and TM6SF2 rs58542926 genetic variants and association tests with respect to hepatic cirrhosis
PNPLA3 rs738409 and TM6SF2 rs58542926 genotypes/alleles | Frequency in CHC patients n (%) | |
|---|---|---|
Fibrosis grade F0-F3 (n = 383) | Cirrhosis F4 (n = 113) | |
PNPLA3 | ||
CC | 234 (61.1%) | 69 (61.1%) |
CG | 124 (32.4%) | 36 (31.9%) |
GG | 25 (6.5%) | 08 (7.1%) |
C | 592 (77%) | 174 (77%) |
G | 174 (23%) | 52 (23%) |
TM6SF2 | ||
CC | 334 (87.2%) | 94 (83.2%) |
CT | 46 (12%) | 18 (15.9%) |
TT | 03 (0.8%) | 01 (0.9%) |
C | 714 (93%) | 206 (91%) |
T | 52 (07%) | 20 (09%) |
OR statistics | OR (95% CI) | p-value |
PNPLA3 | ||
CC vs GG (genotypic model) | 1.09 (0.47–2.51) | 0.98 |
CC vs CG-GG (dominant model) | 1.00 (0.65–1.54) | 0.99 |
CC-CG vs GG (recessive model) | 1.09 (0.48–2.49) | 0.84 |
C vs G (allelic model) | 1.02 (0.71–1.45) | 1.00 |
TM6SF2 | ||
CC vs TT (genotypic model) | 1.18 (0.12–11.52) | 0.56 |
CC vs CT-TT (dominant model) | 1.38 (0.77–2.45) | 0.28 |
CC-CT vs TT (recessive model) | 1.13 (0.12–10.98) | 0.92 |
C vs T (allelic model) | 1.33 (0.78–2.28) | 0.36 |