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Table 1 Baseline characteristics, fibrosis stages, genotype and allelic frequencies in the present study sample set

From: PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study

Characteristics

CHC patients (n = 502)

Age (years)

40 (32–50)

Male (n, %)

242 (47.9%)

BMI

26.8 (24–30)

HCV-RNA (log10)†

4.7 (3.8–5.5)

ALT (IU/L)

59 (40–87)

AST (IU/L)

56 (39–81)

Total bilirubin (mg/dL)

0.8 (0.7–0.9)

Liver stiffness (kPa)

7.9 (5.5–13.9)

Metavir stage

F0-F1

282 (56.2%)

F2

25 (5%)

F3

81 (16.1%)

F4

114 (22.7%)

PNPLA3 rs738409 genotypes & alleles (n = 500)

CC

307 (61.4%)

CG

160 (32%)

GG

33 (6.6%)

C

774 (77.4%)

G

226 (22.6%)

TM6SF2 rs58542926 genotypes & alleles (n = 500)

CC

431 (86.2%)

CT

65 (13%)

TT

04 (0.8%)

C

927 (92.7%)

T

73 (7.3%)

  1. ALT alanine transaminase; AST aspartate transaminase; CHC chronic hepatitis C; BMI body mass index
  2. †Log-transformed values of HCV-RNA viral load are represented here which were originally estimated in IU/ml units
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BMC Gastroenterology

ISSN: 1471-230X

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