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Table 3 Subgroup analysis

From: Nonsteroidal anti-inflammatory drug exposure and the risk of microscopic colitis

Medication

New MC vs. No MC

Registry MC vs. No MC

 

Odds Ratio (95% CI)

p-val

Odds ratio (95% CI)

p-val

Any dose aspirin

2.36 (0.78–7.21)

0.11

2.80 (1.25–6.02)

 < 0.01

Other NSAIDs

2.91 (1.04–7.87)

0.03

2.56 (1.26–5.16)

 < 0.01

Any aspirin or NSAIDs

2.70 (1.04–7.36)

0.03

3.02 (1.55–6.07)

 < 0.01

PPIs

0.69 (0.20–2.15)

0.53

0.91 (0.42–1.92)

0.81

H2RAs

1.42 (0.06–11.59)

0.56

2.62 (0.68–10.73)

0.16

SSRIs

1.17 (0.41–3.38)

0.76

1.62 (0.81–3.29)

0.16

Statins

0.84 (0.27–2.53)

0.75

1.09 (0.52–2.25)

0.81

ACE-Is

0.35 (0.02–2.44)

0.47

0.24 (0.04–1.08)

0.06

ARBs

1.45 (0.21–6.96)

0.64

0.43 (0.10–1.58)

0.25

  1. P-values and odds ratios (OR) were calculated comparing rate of medication use among the two groups of microscopic colitis (MC) patients independently compared to the no-MC group to assess homogeneity of findings. 95% CI: 95% Confidence Interval, NSAIDs: non-steroidal anti-inflammatory drugs, PPIs: proton pump inhibitors, H2RAs: histamine-2 receptor antagonists, SSRIs: selective serotonin reuptake inhibitors, ACE-Is: angiotensin converting enzyme inhibitors, ARBs: angiotensin receptor blockers
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BMC Gastroenterology

ISSN: 1471-230X

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