Table 3 The multivariable logistic regression analysis for analyzing the risk factors for early death of advanced HCC
Characteristics | AJCC stage IVA | AJCC stage IVB | ||||
|---|---|---|---|---|---|---|
OR | 95% CI | P-value | OR | 95% CI | P-value | |
Age (%) | ||||||
 <  = 40 | Ref |  |  | Ref |  |  |
41–60 | 4.097 | 1.158–17.179 | 0.037 | 1.728 | 1.090–2.740 | 0.020 |
61–80 | 4.444 | 1.259–18.591 | 0.027 | 1.804 | 1.137–2.864 | 0.012 |
 > 80 | 2.675 | 0.700–11.897 | 0.167 | 1.440 | 0.864–2.403 | 0.161 |
Marital status (%) | ||||||
Unmarried | NA | NA | NA | Ref | Â | Â |
Married | NA | NA | NA | 1.066 | 0.903–1.259 | 0.449 |
Divorced or Separated | NA | NA | NA | 1.032 | 0.831–1.284 | 0.774 |
Widowed | NA | NA | NA | 1.038 | 0.796–1.358 | 0.782 |
Unknown | NA | NA | NA | 1.004 | 0.732–1.384 | 0.978 |
Tumor size (%) | ||||||
 <  = 20 mm | Ref |  |  | NA | NA | NA |
21–50 mm | 1.642 | 0.746–3.880 | 0.235 | NA | NA | NA |
51–100 mm | 2.571 | 1.173–6.054 | 0.023 | NA | NA | NA |
 > 100 mm | 5.521 | 2.443–13.370 |  < 0.001 | NA | NA | NA |
Unknown | 4.376 | 1.897–10.795 |  < 0.001 | NA | NA | NA |
Histological grade (%) | ||||||
Grade I–II | Ref |  |  | Ref |  |  |
Grade III–IV | 1.754 | 1.079–2.869 | 0.024 | 2.178 | 1.703–2.792 |  < 0.001 |
Unknown | 0.826 | 0.590–1.156 | 0.266 | 1.400 | 1.176–1.666 |  < 0.001 |
AFP (%) | ||||||
Negative | Ref | Â | Â | Ref | Â | Â |
Positive | 1.796 | 1.191–2.728 | 0.006 | 1.462 | 1.194–1.791 |  < 0.001 |
Unknown | 1.387 | 0.844–2.289 | 0.198 | 1.240 | 0.984–1.563 | 0.068 |
Fibrosis scores (%) | ||||||
Ishak 0–4 | Ref |  |  | Ref |  |  |
Ishak 5–6 | 2.528 | 1.174–5.650 | 0.020 | 1.073 | 0.735–1.566 | 0.715 |
Unknown | 2.043 | 0.993–4.369 | 0.058 | 1.244 | 0.878–1.762 | 0.218 |
T stage (%) | ||||||
T1–2 | Ref |  |  | Ref |  |  |
T3–4 | 2.061 | 1.501–2.838 |  < 0.001 | 1.363 | 1.171–1.588 |  < 0.001 |
TX | 1.714 | 0.977–3.022 | 0.061 | 1.249 | 1.030–1.516 | 0.024 |
N stage (%) | ||||||
N0 | NA | NA | NA | Ref | Â | Â |
N1 | NA | NA | NA | 1.210 | 1.029–1.426 | 0.022 |
NX | NA | NA | NA | 0.994 | 0.821–1.206 | 0.954 |
Bone metastasis (%) | ||||||
No | NA | NA | NA | Ref | Â | Â |
Yes | NA | NA | NA | 1.239 | 1.050–1.463 | 0.011 |
Unknown | NA | NA | NA | 0.715 | 0.487–1.057 | 0.089 |
Lung metastasis (%) | ||||||
No | NA | NA | NA | Ref | Â | Â |
Yes | NA | NA | NA | 2.195 | 1.901–2.537 |  < 0.001 |
Unknown | NA | NA | NA | 1.214 | 0.839–1.763 | 0.304 |
Surgery (%) | ||||||
No | Ref | Â | Â | Ref | Â | Â |
Local tumor destruction | 0.187 | 0.053–0.502 | 0.003 | 0.139 | 0.067–0.265 |  < 0.001 |
Wedge resection | 0.083 | 0.012–0.332 | 0.002 | 0.204 | 0.089–0.441 |  < 0.001 |
Lobectomy | 0.020 | 0.001–0.108 |  < 0.001 | 0.077 | 0.032–0.165 |  < 0.001 |
Surgery but the specific operation unknown | NA | NA | NA | 0.649 | 0.141–2.597 | 0.554 |
Radiotherapy (%) | ||||||
No/Unknown | Ref | Â | Â | Ref | Â | Â |
Yes | 0.080 | 0.041–0.145 |  < 0.001 | 0.342 | 0.281–0.415 |  < 0.001 |
Chemotherapy (%) | ||||||
No/Unknown | Ref | Â | Â | Ref | Â | Â |
Yes | 0.144 | 0.109–0.190 |  < 0.001 | 0.163 | 0.142–0.187 |  < 0.001 |