Table 1 Characteristics with advanced HCC patients
Characteristics | AJCC stage IVA | AJCC stage IVB | ||||||
|---|---|---|---|---|---|---|---|---|
Overall | Non early death | Early death | P (χ2) | Overall | Non early death | Early death | P (χ2) | |
(N = 1392) | (N = 771) | (N = 621) | (N = 5211) | (N = 1940) | (N = 3271) | |||
Age (%) | Â | Â | Â | 0.007 | Â | Â | Â | 0.005 |
<  = 40 | 28 (2.0) | 24 (3.1) | 4 (0.6) |  | 109 (2.1) | 58 (3.0) | 51 (1.6) |  |
41–60 | 554 (39.8) | 313 (40.6) | 241 (38.8) |  | 2084 (40.0) | 766 (39.5) | 1318 (40.3) |  |
61–80 | 720 (51.7) | 388 (50.3) | 332 (53.5) |  | 2571 (49.3) | 959 (49.4) | 1612 (49.3) |  |
 > 80 | 90 (6.5) | 46 (6.0) | 44 (7.1) |  | 447 (8.6) | 157 (8.1) | 290 (8.9) |  |
Gender (%) | Â | Â | Â | 0.437 | Â | Â | Â | 0.538 |
Female | 258 (18.5) | 149 (19.3) | 109 (17.6) | Â | 972 (18.7) | 353 (18.2) | 619 (18.9) | Â |
Male | 1134 (81.5) | 622 (80.7) | 512 (82.4) | Â | 4239 (81.3) | 1587 (81.8) | 2652 (81.1) | Â |
Race (%) | Â | Â | Â | 0.599 | Â | Â | Â | 0.129 |
White | 992 (71.3) | 543 (70.4) | 449 (72.3) | Â | 3573 (68.6) | 1363 (70.3) | 2210 (67.6) | Â |
Black | 225 (16.2) | 125 (16.2) | 100 (16.1) | Â | 830 (15.9) | 292 (15.1) | 538 (16.4) | Â |
Others* | 175 (12.6) | 103 (13.4) | 72 (11.6) | Â | 808 (15.5) | 285 (14.7) | 523 (16.0) | Â |
Marital status (%) | Â | Â | Â | 0.379 | Â | Â | Â | 0.058 |
Unmarried | 340 (24.4) | 182 (23.6) | 158 (25.4) | Â | 1344 (25.8) | 474 (24.4) | 870 (26.6) | Â |
Married | 670 (48.1) | 387 (50.2) | 283 (45.6) | Â | 2372 (45.5) | 934 (48.1) | 1438 (44.0) | Â |
Divorced or separated | 208 (14.9) | 106 (13.7) | 102 (16.4) | Â | 754 (14.5) | 274 (14.1) | 480 (14.7) | Â |
Widowed | 104 (7.5) | 55 (7.1) | 49 (7.9) | Â | 478 (9.2) | 164 (8.5) | 314 (9.6) | Â |
Unknown | 70 (5.0) | 41 (5.3) | 29 (4.7) | Â | 263 (5.0) | 94 (4.8) | 169 (5.2) | Â |
Tumor size (%) |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
 <  = 20 mm | 49 (3.5) | 39 (5.1) | 10 (1.6) |  | 184 (3.5) | 76 (3.9) | 108 (3.3) |  |
21–50 mm | 323 (23.2) | 232 (30.1) | 91 (14.7) |  | 813 (15.6) | 375 (19.3) | 438 (13.4) |  |
51–100 mm | 518 (37.2) | 293 (38.0) | 225 (36.2) |  | 1534 (29.4) | 621 (32.0) | 913 (27.9) |  |
 > 100 mm | 275 (19.8) | 121 (15.7) | 154 (24.8) |  | 1149 (22.0) | 413 (21.3) | 736 (22.5) |  |
Unknown | 227 (16.3) | 86 (11.2) | 141 (22.7) | Â | 1531 (29.4) | 455 (23.5) | 1076 (32.9) | Â |
Histological grade (%) |  |  |  | 0.050 |  |  |  |  < 0.001 |
Grade I–II | 284 (20.4) | 169 (21.9) | 115 (18.5) |  | 889 (17.1) | 438 (22.6) | 451 (13.8) |  |
Grade III–IV | 160 (11.5) | 76 (9.9) | 84 (13.5) |  | 665 (12.8) | 202 (10.4) | 463 (14.2) |  |
Unknown | 948 (68.1) | 526 (68.2) | 422 (68.0) | Â | 3657 (70.2) | 1300 (67.0) | 2357 (72.1) | Â |
AFP (%) |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
Negative | 188 (13.5) | 132 (17.1) | 56 (9.0) | Â | 624 (12.0) | 290 (14.9) | 334 (10.2) | Â |
Positive | 989 (71.0) | 526 (68.2) | 463 (74.6) | Â | 3383 (64.9) | 1212 (62.5) | 2171 (66.4) | Â |
Unknown | 215 (15.4) | 113 (14.7) | 102 (16.4) | Â | 1204 (23.1) | 438 (22.6) | 766 (23.4) | Â |
Fibrosis scores (%) |  |  |  | 0.016 |  |  |  |  < 0.001 |
Ishak 0–4 | 57 (4.1) | 42 (5.4) | 15 (2.4) |  | 193 (3.7) | 102 (5.3) | 91 (2.8) |  |
Ishak 5–6 | 267 (19.2) | 149 (19.3) | 118 (19.0) |  | 782 (15.0) | 317 (16.3) | 465 (14.2) |  |
Unknown | 1068 (76.7) | 580 (75.2) | 488 (78.6) | Â | 4236 (81.3) | 1521 (78.4) | 2715 (83.0) | Â |
T stage (%) |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
T1–2 | 497 (35.7) | 346 (44.9) | 151 (24.3) |  | 1604 (30.8) | 686 (35.4) | 918 (28.1) |  |
T3–4 | 779 (56.0) | 378 (49.0) | 401 (64.6) |  | 2462 (47.2) | 888 (45.8) | 1574 (48.1) |  |
TX | 116 (8.3) | 47 (6.1) | 69 (11.1) | Â | 1145 (22.0) | 366 (18.9) | 779 (23.8) | Â |
N stage (%) |  < 0.001 | |||||||
N0 | NA | NA | NA | Â | 3071 (58.9) | 1208 (62.3) | 1863 (57.0) | Â |
N1 | 1392 (100) | N = 771 (100) | N = 621 (100) |  | 1224 (23.5) | 433 (22.3) | 791 (24.2) |  |
NX | NA | NA | NA | Â | 916 (17.6) | 299 (15.4) | 617 (18.9) | Â |
Bone metastasis (%) |  < 0.001 | |||||||
No | NA | NA | NA | Â | 3441 (66.0) | 1207 (62.2) | 2234 (68.3) | Â |
Yes | NA | NA | NA | Â | 1527 (29.3) | 650 (33.5) | 877 (26.8) | Â |
Unknown | NA | NA | NA | Â | 243 (4.7) | 83 (4.3) | 160 (4.9) | Â |
Brain metastasis (%) | 0.450 | |||||||
No | NA | NA | NA | Â | 4801 (92.1) | 1797 (92.6) | 3004 (91.8) | Â |
Yes | NA | NA | NA | Â | 114 (2.2) | 43 (2.2) | 71 (2.2) | Â |
Unknown | NA | NA | NA | Â | 296 (5.7) | 100 (5.2) | 196 (6.0) | Â |
Lung metastasis (%) |  < 0.001 | |||||||
No | NA | NA | NA | Â | 2856 (54.8) | 1289 (66.4) | 1567 (47.9) | Â |
Yes | NA | NA | NA | Â | 2098 (40.3) | 555 (28.6) | 1543 (47.2) | Â |
Unknown | NA | NA | NA | Â | 257 (4.9) | 96 (4.9) | 161 (4.9) | Â |
Surgery (%) |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
No | 1291 (92.7) | 677 (87.8) | 614 (98.9) | Â | 5036 (96.6) | 1798 (92.7) | 3238 (99.0) | Â |
Local tumor destruction | 45 (3.2) | 41 (5.3) | 4 (0.6) | Â | 76 (1.5) | 65 (3.4) | 11 (0.3) | Â |
Wedge resection | 23 (1.7) | 21 (2.7) | 2 (0.3) | Â | 34 (0.7) | 24 (1.2) | 10 (0.3) | Â |
Lobectomy | 33 (2.4) | 32 (4.2) | 1 (0.2) | Â | 54 (1.0) | 46 (2.4) | 8 (0.2) | Â |
Surgery but the specific operation unknown | NA | NA | NA | Â | 11 (0.2) | 7 (0.4) | 4 (0.1) | Â |
Radiotherapy (%) |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
No/Unknown | 1262 (90.7) | 654 (84.8) | 608 (97.9) | Â | 4377 (84.0) | 1416 (73.0) | 2961 (90.5) | Â |
Yes | 130 (9.3) | 117 (15.2) | 13 (2.1) | Â | 834 (16.0) | 524 (27.0) | 310 (9.5) | Â |
Chemotherapy (%) |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
No/Unknown | 757 (54.4) | 283 (36.7) | 474 (76.3) | Â | 3339 (64.1) | 754 (38.9) | 2585 (79.0) | Â |
Yes | 635 (45.6) | 488 (63.3) | 147 (23.7) | Â | 1872 (35.9) | 1186 (61.1) | 686 (21.0) | Â |