Table 1 Patient demographics and clinical characteristics†
Characteristic | Survivor Group (for 90 days) (n = 1006) | Non-survivor Group (for 90 days) (n = 856) | P value |
|---|---|---|---|
Age, y | 41.0 (33.0,50.0) | 49.0 (41.0, 58.0) | < 0.001 |
Sex | |||
Male | 901 (89.6) | 755 (88.2) | 0.351 |
Female | 105 (10.4) | 101 (11.8) | |
WBC (× 109/L) | 7.21 (5.60, 9.08) | 7.85 (5.76, 10.59) | < 0.001 |
Hb (g/L) | 124.0 (110.0,136.3) | 120.0 (102.0, 134.0) | < 0.001 |
PLT (× 109/L) | 121.0 (88.0, 158.3) | 102.0 (66.0,143.0) | < 0.001 |
ALT (U/L) | 368.5 (118.8, 900.5) | 322.0 (101.0, 848.0) | 0.178 |
AST (U/L) | 219.5 (112.8, 503.5) | 257.0 (128.3, 609.5) | 0.005 |
ALB (g/L) | 33.0 (30.1, 35.7) | 31.8 (29.0, 34.6) | < 0.001 |
GLB (g/L) | 27.9 (23.9, 32.3) | 28.5 (24.2, 33.3) | 0.088 |
TBil (µmol/L) | 338.7 (256.2, 438.9) | 412.3 (307.1, 527.9) | < 0.001 |
INR | 2.12 (1.83, 2.56) | 2.82 (2.21, 3.70) | < 0.001 |
Na (mmol/L) | 137.4 (135.0, 139.5) | 136.0 (132.4, 138.7) | < 0.001 |
Cr (µmol/L) | 69.0 (61.0, 79.2) | 73.1 (62.0, 92.0) | < 0.001 |
AFP (ng/mL) | 78.6 (29.5, 193.8) | 29.8 (10.5, 95.1) | < 0.001 |
TSH (µIU/mL) | 0.525 (0.188, 1.137) | 0.265 (0.092, 0.720) | < 0.001 |
HBeAg | |||
Positive | 364 (36.2) | 233 (27.2) | < 0.001 |
Negative | 642 (63.8) | 623 (72.8) | |
HBV DNA (IU/mL, log10) | 5.12 (3.67, 6.53) | 5.28 (3.70, 6.91) | 0.191 |
MELD score | 24 (22, 27) | 29 (25, 33) | < 0.001 |
MELD-Na score | 24.6 (22.2, 27.5) | 30.5 (25.9, 36.2) | < 0.001 |
CTP score | 10 (9,11) | 11 (10, 12) | < 0.001 |
Pre-existing chronic liver diseases | |||
Chronic hepatitis | 517 (51.4) | 243 (28.4) | < 0.001 |
Cirrhosis | 489 (48.6) | 613 (71.6) | |
Ascite | |||
None | 418 (41.6) | 312 (36.4) | < 0.001 |
Grade 1–2 | 490 (48.7) | 392 (45.8) | |
Grade 3 | 98 (9.7) | 152 (17.8) | |
Hepatorenal Syndrome | |||
No | 997 (99.1) | 790 (92.3) | < 0.001 |
Yes | 9 (0.9) | 66 (7.7) | |
Hepatic Encephalopathy | |||
None | 915 (91.0) | 592 (69.2) | < 0.001 |
Grade 1–2 | 81 (8.1) | 220 (25.7) | |
Grade 3–4 | 10 (1.0) | 44 (5.1) | |
Gastrointestinal Bleeding | |||
No | 1001 (99.5) | 835 (97.5) | < 0.001 |
Yes | 5 (0.5) | 21 (2.5) | |
Infection | |||
No Yes | 361 (35.9) 645 (64.1) | 168 (19.6) 688 (80.4) | < 0.001 |
Antivirus Drug | |||
None | 43 (4.3) | 96 (11.2) | < 0.001 |
LAM | 31 (3.1) | 29 (3.4) | |
ADV | 4 (0.4) | 3 (0.4) | |
ETV | 831 (82.6) | 658 (76.9) | |
TDF | 43 (4.3) | 26 (3.0) | |
Ldt | 17 (1.7) | 9 (1.1) | |
Combination therapy | 37 (3.7) | 35 (4.1) | |