Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid lesions of gallbladder ≥ 1 cm

Table 2 The enhancement extent of ALGs compared to normal GB wall

Final diagnosis	n	Enhancement extent in early phase				Contrast agent wash-out within the lesion
Final diagnosis	n	Hyper-	Iso-	Hypo-	Non-	Earlier	Same	Later
Malignant lesions	34	25 (73.5%)	5 (14.7%)	4 (11.8%)	0 (0%)	31 (91.2%)	3 (8.8%)	0 (0%)
Benign lesions	146	11 (7.5%)	121(82.9%)	12 (8.2%)	2 (1.4%)	19 (13.2%)	125 (86.8%)	0 (0%)
Cholesterol polyp	100	5 (5.0%)	88 (88.0%)	7 (7.0%)	0 (0%)	10 (10%)	90 (90%)	0 (0%)
Adenoma	29	5 (17.2%)	21 (72.4%)	3 (10.4%)	0 (0%)	7 (24.1%)	22 (75.9%)	0 (0%)
Adenomyomatosis	10	1 (10.0%)	8 (80.0%)	1 (10.0%)	0 (0%)	2 (20.0%)	8 (80.0%)	0 (0%)
Chronic cholecystitis	3	0 (0%)	2 (66.7%)	1 (33.3%)	0 (0%)	0 (0%)	3 (100%)	0 (0%)
Gallstone	2	0 (0%)	0 (0%)	0 (0%)	2 (100%)	–	–	–
Hyperplastic polyp	1	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)
Metaplastic polyp	1	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)

^*There was significant difference between benign and malignant GB diseases in enhancement pattern on CEUS image during both arterial phase and venous phase (arterial phase: χ² = 79.200, P = 0.000; venous phase: χ² = 82.808, P = 0.000); there was significant difference between cholesterol polyps and adenoma groups in the enhancement pattern of venous phase, χ² = 3.927, P = 0.048

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