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Table 2 Univariable and multivariable analyses to identify independent prognostic indicators of overall survival in pateints with HCC

From: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with hepatocellular carcinoma subjected to hepatectomy

Variables

Overall survival

Univariable

Multivariable

HR (95% CI)

p value

HR (95% CI)

p value

Age (years)

0.988 (0.980, 0.996)

0.003

0.992 (0.984,1.000)

0.050

Male sex

1.442 (1.085, 1.917)

0.012

1.293 (0.967, 1.729)

0.083

Positive HBsAg

1.320 (0.995, 1.751)

0.054

  

Positive anti-HCV

0.634 (0.263, 1.531)

0.311

  

Child–Pugh grade B

1.340 (0.962, 1.886)

0.084

  

AFP ≥ 400 ng/mL

1.767 (1.482, 2.107)

 < 0.001

1.346 (1.120, 1.618)

0.002

FAR

1.961 (1.632, 2.355)

 < 0.001

1.230 (1.001, 1.510)

0.048

NLR

1.936 (1.611, 2.326)

 < 0.001

1.045 (0.801, 1.362)

0.748

PLR

1.839 (1.466, 2.307)

 < 0.001

0.739 (0.548, 0.998)

0.049

MLR

1.945 (1.632, 2.319)

 < 0.001

1.166 (0.940, 1.446)

0.163

SII

2.210 (1.809, 2.700)

 < 0.001

1.455 (1.053, 2.010)

0.023

CSPH

1.390 (1.050, 1.840)

0.021

1.369 (1.022, 1.833)

0.035

Ascites

1.471 (1.149, 1.883)

0.002

1.186(0.914, 1.539)

0.198

Cirrhosis

1.085 (0.910, 1.294)

0.364

  

Tumor size ≥ 5 cm

2.708 (2.200, 3.334)

 < 0.001

1.500 (1.180, 1.907)

0.001

Multiple number

1.093 (0.871, 1.371)

0.441

  

MVI

3.484 (2.920, 4.156)

 < 0.001

1.522 (0.711, 3.256)

0.279

BCLC stage C

8.773 (3.619, 21.267)

 < 0.001

2.693 (0.835, 8.686)

0.097

Blood loss ≥ 400 ml

2.028(1.701, 2.417)

 < 0.001

1.232 (1.011, 1.501)

0.039

Blood transfusion

1.554 (1.225, 1.971)

 < 0.001

1.083 (0.843, 1.392)

0.534

Major hepatectomy

1.792 (1.498, 2.143)

 < 0.001

1.075 (0.881, 1.311)

0.477

  1. HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; AFP, alpha-fetoprotein; FAR, fibrinogen-albumin ratio; NLR, neutrophil–lymphocyte ratio; MLR, monocyte-lymphocyte ratio; PLR, platelet–lymphocyte ratio; SII, systemic immune–inflammation index; CSPH, clinically significant portal hypertension; MVI, macrovascular invasion; BCLC, Barcelona Clinical Liver Cancer
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BMC Gastroenterology

ISSN: 1471-230X

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