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Table 2 Univariable and multivariable analyses to identify independent prognostic indicators of overall survival in pateints with HCC

From: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with hepatocellular carcinoma subjected to hepatectomy

Variables Overall survival
Univariable Multivariable
HR (95% CI) p value HR (95% CI) p value
Age (years) 0.988 (0.980, 0.996) 0.003 0.992 (0.984,1.000) 0.050
Male sex 1.442 (1.085, 1.917) 0.012 1.293 (0.967, 1.729) 0.083
Positive HBsAg 1.320 (0.995, 1.751) 0.054   
Positive anti-HCV 0.634 (0.263, 1.531) 0.311   
Child–Pugh grade B 1.340 (0.962, 1.886) 0.084   
AFP ≥ 400 ng/mL 1.767 (1.482, 2.107)  < 0.001 1.346 (1.120, 1.618) 0.002
FAR 1.961 (1.632, 2.355)  < 0.001 1.230 (1.001, 1.510) 0.048
NLR 1.936 (1.611, 2.326)  < 0.001 1.045 (0.801, 1.362) 0.748
PLR 1.839 (1.466, 2.307)  < 0.001 0.739 (0.548, 0.998) 0.049
MLR 1.945 (1.632, 2.319)  < 0.001 1.166 (0.940, 1.446) 0.163
SII 2.210 (1.809, 2.700)  < 0.001 1.455 (1.053, 2.010) 0.023
CSPH 1.390 (1.050, 1.840) 0.021 1.369 (1.022, 1.833) 0.035
Ascites 1.471 (1.149, 1.883) 0.002 1.186(0.914, 1.539) 0.198
Cirrhosis 1.085 (0.910, 1.294) 0.364   
Tumor size ≥ 5 cm 2.708 (2.200, 3.334)  < 0.001 1.500 (1.180, 1.907) 0.001
Multiple number 1.093 (0.871, 1.371) 0.441   
MVI 3.484 (2.920, 4.156)  < 0.001 1.522 (0.711, 3.256) 0.279
BCLC stage C 8.773 (3.619, 21.267)  < 0.001 2.693 (0.835, 8.686) 0.097
Blood loss ≥ 400 ml 2.028(1.701, 2.417)  < 0.001 1.232 (1.011, 1.501) 0.039
Blood transfusion 1.554 (1.225, 1.971)  < 0.001 1.083 (0.843, 1.392) 0.534
Major hepatectomy 1.792 (1.498, 2.143)  < 0.001 1.075 (0.881, 1.311) 0.477
  1. HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; AFP, alpha-fetoprotein; FAR, fibrinogen-albumin ratio; NLR, neutrophil–lymphocyte ratio; MLR, monocyte-lymphocyte ratio; PLR, platelet–lymphocyte ratio; SII, systemic immune–inflammation index; CSPH, clinically significant portal hypertension; MVI, macrovascular invasion; BCLC, Barcelona Clinical Liver Cancer