Table 3 Comparisons among patients with AKI progression, regression and fluctuated in-situ
Variables | Fluctuated in-situ N = 40 | Regression N = 96 | Progression | P value |
|---|---|---|---|---|
N = 81 | ||||
Age (years) | 55.5 ± 9.1 | 50.6 ± 12.1 | 56.4 ± 12.7 | 0.003 |
Male-n (%) | 28 (70.0) | 81 (84.4) | 60 (74.1) | 0.107 |
Death-n (%) | 16 (40.0) | 32 (33.3) | 72 (88.9) |  < 0.001 |
MAP (mmHg) | 90.6 ± 11.9 | 86.1 ± 17.3 | 90.8 ± 12.7 | 0.074 |
Heart rate (bpm) | 88.4 ± 15.9 | 89.0 ± 16.1 | 84.5 ± 12.6 | 0.115 |
Baseline Cr (μmol/L) | 78.7 ± 39.3 | 78.4 ± 33.0 | 95.8 ± 65.4 | 0.041 |
Baseline eGFR (ml/min/1.73m2) | 110.3 ± 53.5 | 111.2 ± 47.6 | 107.1 ± 77.3 | 0.903 |
Peak Cr (μmol/L) | 147.5 ± 82.1 | 173.6 ± 112.1 | 295.3 ± 154.1 |  < 0.001 |
CA-AKI/HA-AKI-n | 11/29 | 28/68 | 17/64 | 0.447 |
Initial ICA-AKI stage-n | ||||
Stage 1/2/3 | 28/10/2 | 58/23/15 | 46/25/10 | 0.383 |
Peak ICA-AKI stage-n | ||||
Stage 1/2/3 | 26/12/2 | 49/29/18 | 9/19/53 |  < 0.001 |
Type of AKI-n(%) |  |  |  |  < 0.001 |
ATN | 2 (5.0) | 15 (15.6) | 56 (32.1) | Â |
PRA | 22 (55.0) | 77 (80.2) | 8 (9.9) | Â |
HRS | 16 (40.0) | 15 (15.6) | 47 (58.0) | Â |
Etiology of liver disease- n (%) |  |  |  |  < 0.001 |
Hepatitis B | 19 (47.5) | 35 (36.5) | 48 (59.3) | Â |
Alcohol | 10 (25.0) | 50 (52.1) | 51 (25.9) | Â |
Other causes | 11 (27.5) | 11 (11.5) | 12 (14.8) | Â |
Complications during hospitalization-n (%) | ||||
Ascites | 26 (65.0) | 70 (72.9) | 58 (71.6) | 0.643 |
HE | 15 (35.0) | 19 (19.8) | 33 (40.7) | 0.008 |
GI bleeding | 9 (22.5) | 22 (22.9) | 19 (23.5) | 0.992 |
Bacterial infection | 30 (75.0) | 74 (77.1) | 70 (86.4) | 0.198 |
Shock | 2 (5.0) | 10 (10.4) | 13 (18.0) | 0.182 |
Mechanical ventilation | 0 (0.0) | 3 (3.1) | 8 (9.9) | 0.034 |
Parameters at diagnosis of AKI | ||||
WBC (× 109/L) | 9.6 ± 6.6 | 11.2 ± 7.1 | 11.9 ± 7.0 | 0.219 |
PLT (× 109/L) | 85.4 ± 66.0 | 100.4 ± 63.6 | 89.9 ± 67.4 | 0.383 |
ALB (g/L) | 29.3 ± 5.1 | 28.0 ± 4.6 | 27.5 ± 4.8 | 0.148 |
TBIL (μmol/L) | 270.9 ± 185.1 | 242.4 ± 146.9 | 308.2 ± 168 | 0.030 |
INR | 2.2 ± 1.1 | 2.4 ± 1.0 | 3.0 ± 2.0 | 0.005 |
PT (s) | 29.2 ± 13.4 | 28.0 ± 9.5 | 31.2 ± 14.7 | 0.237 |
BUN (mmol/L) | 11.3 ± 5.7 | 13.9 ± 9.6 | 16.5 ± 7.7 | 0.004 |
sCr (μmol/L) | 135.6 ± 77.7 | 157.3 ± 84.7 | 183.1 ± 86.9 | 0.011 |
Serum Na+ (mmol/L) | 132.4 ± 4.8 | 132.3 ± 6.4 | 130.1 ± 7.3 | 0.045 |
Serum K+ (mmol/L) | 4.1 ± 0.7 | 3.9 ± 0.7 | 5.3 ± 10.3 | 0.316 |
CTP | 11.0 ± 1.5 | 11.8 ± 1.4 | 12.3 ± 1.7 |  < 0.001 |
MELD | 24.7 ± 7.0 | 25.7 ± 7.9 | 31.5 ± 8.4 |  < 0.001 |
MELD-Na | 30.3 ± 10.8 | 32.0 ± 11.7 | 40.7 ± 13.6 |  < 0.001 |