Fig. 2

Dose–response curves of (A) EP2 agonist ONO-AE1-259 and (B) PGE₂ and EP4 agonist, TCS 2510, experiments. X-axis: ligand concentrations scaled logarithmically. Y-axis: changes in SCC. A: Large dots (black) show increases in SCC as a response to increasing EP2 agonist concentrations. The unbroken line in cyan resembles single receptor model (srm) fitting, while the long dotted line in blue resembles two receptor model (trm) fitting. B: Triangles (black) indicate increases in SCC as a response to increasing PGE₂ concentrations. Large dots (black) show increases in SCC as a response to increasing EP4 agonist concentrations. Dotted and long dotted lines (in blue colors) resemble single (srm) and two receptor model (trm) fitting for PGE₂ respectively. The unbroken and the medium dotted lines (in red colors) show trm and srm respectively for EP4 agonist. The trm fits data points more closely