A comparison of clinical pathologic characteristics between alpha-fetoprotein negative and positive hepatocellular carcinoma patients from Eastern and Southern China

Table 2 Association between serum AFP levels and clinical pathologic features

		n	Median	P25–P75	Mean rank	Test statistic	P
Tumor size^a	< 10 cm	569	82.53	7.08–1000	379.83	− 7.593	0.000
(largest in diameter)	≥ 10 cm	279	928.70	51.83–3000	515.59
Liver cirrhosis^a	No	439	211	7.31–1494.20	505.12	− 0.845	0.398
	Yes	553	160.7	11.29–1210.00	489.66
PVT^a	No	711	97.63	6.98–1000.00	459.53	− 6.472	0.000
	Yes	281	844.1	49.49–1914.15	590.04
Metastasis^a	No	699	138.00	7.60–1210	479.39	− 2.909	0.004
	Yes	293	390.10	17.67–1210	537.33
Types of tumor^b	Single nodule	357	44.31	5.80–882.69	413.75	77.401	0.000
	Multiple nodules	244	158.67	9.27–1210	480.64
	Infiltrative	139	190.70	15.39–1097.22	514.60
	Large tumor	252	993.00	79.95–3000.00	619.10
TD^b	Low	44	94.98	7.68–750.92	104.66	4.769	0.092
	Medium	111	86.59	4.33–780.26	92.46
	High	17	63.94	3.34–64.84	70.67
Child–Pugh^b	A	585	77.02	6.56–1000.00	442.59	51.720	0.000
	B	289	686.4	25.07–2644.37	557.29
	C	116	1000	99.57–1210	608.37
BCLC^b	0	22	12.65	4.34–70.97	233.55	54.373	0.000
	A	201	39.50	5.16–541.49	289.41
	B	221	334.60	17.50–1955.01	394.89
	C	257	586.10	28.19–1210	405.95
	D	34	1000	158.68–3000.00	457.93
Clinical staging^b	I	53	9.97	3.64–193.50	99.79	22.725	0.000
	II	37	213.21	6.56–843.00	140.82
	III	105	155.80	14.02–1210.00	146.92
	IV	92	887.50	23.87–1210.00	167.41

^aMann–Whitney U
^bKruskai–Wallis H
PT: Thrombosis of portal vein; Metastasis: lymph nodes or distant organ metastasis; TD: tumor differentiation; BCLC: Barcelona clinic liver cancer staging

ISSN: 1471-230X