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Table 3 Univariate and multivariate analyses for disease free survival in stage I colorectal cancer

From: Survival after curative resection for stage I colorectal mucinous adenocarcinoma

Variable Without recurrence (n = 449) With recurrence (n = 81) Univariate p value Multivariate
     HR (95% CI) p value
Gender      
 Male 241 (53.7%) 48 (59.3%) 0.268   
 Female 208 (46.3%) 33 (40.7%)    
Age      
 ≤ 65 287 (63.9%) 44 (54.3%) 0.090   
 > 65 162 (36.1%) 37 (45.7%)    
Preoperative CEA      
 ≤ 5 400 (89.1%) 66 (81.5%) 0.042* 1.863 (1.049–3.310) 0.034*
 > 5 49 (10.9%) 15 (18.5%)    
T classification      
 T1 149 (33.2%) 21 (25.9%) 0.243   
 T2 300 (66.8%) 60 (74.1%)    
Lesion location      
 Colon 144 (32.1%) 16 (19.8%) 0.036* 1.813 (1.041–3.156) 0.035*
 Rectal 305 (67.9%) 65 (80.2%)    
Size      
 < 3 cm 260 (57.9%) 49 (60.5%) 0.527   
 ≥ 3 cm 189 (42.1%) 32 (39.5%)    
Mucinous histology      
 MAC 48 (10.7%) 10 (12.3%) 0.746   
 Non-MAC 401 (89.3%) 71 (87.7%)    
LVI      
 (−) 437 (97.3%) 74 (91.4%) 0.004* 3.587 (1.627–7.909) 0.002*
 (+) 12(2.7%) 7 (8.6%)    
Less than 12 lymph nodes      
 Yes 76 (16.9%) 21 (25.9%) 0.583   
 No 373 (83.1%) 60 (74.1%)    
dMMR      
 Positive 14 (2.7%) 7 (8.6%) 0.021* 2.848 (1.300–6.238) 0.009*
 Negative 435 (97.3%) 74 (91.4%)    
  1. The bold and *  indicates p < 0.05
  2. MAC mucinous adenocarcinomas, CEA carcinoembryonic antigen, dMMR deficient mismatch repair