Table 3 Univariate and multivariate analyses for disease free survival in stage I colorectal cancer
From: Survival after curative resection for stage I colorectal mucinous adenocarcinoma
| Variable | Without recurrence (n = 449) | With recurrence (n = 81) | Univariate p value | Multivariate | |
|---|---|---|---|---|---|
| HR (95% CI) | p value | ||||
| Gender | |||||
| Male | 241 (53.7%) | 48 (59.3%) | 0.268 | ||
| Female | 208 (46.3%) | 33 (40.7%) | |||
| Age | |||||
| ≤ 65 | 287 (63.9%) | 44 (54.3%) | 0.090 | ||
| > 65 | 162 (36.1%) | 37 (45.7%) | |||
| Preoperative CEA | |||||
| ≤ 5 | 400 (89.1%) | 66 (81.5%) | 0.042* | 1.863 (1.049–3.310) | 0.034* |
| > 5 | 49 (10.9%) | 15 (18.5%) | |||
| T classification | |||||
| T1 | 149 (33.2%) | 21 (25.9%) | 0.243 | ||
| T2 | 300 (66.8%) | 60 (74.1%) | |||
| Lesion location | |||||
| Colon | 144 (32.1%) | 16 (19.8%) | 0.036* | 1.813 (1.041–3.156) | 0.035* |
| Rectal | 305 (67.9%) | 65 (80.2%) | |||
| Size | |||||
| < 3 cm | 260 (57.9%) | 49 (60.5%) | 0.527 | ||
| ≥ 3 cm | 189 (42.1%) | 32 (39.5%) | |||
| Mucinous histology | |||||
| MAC | 48 (10.7%) | 10 (12.3%) | 0.746 | ||
| Non-MAC | 401 (89.3%) | 71 (87.7%) | |||
| LVI | |||||
| (−) | 437 (97.3%) | 74 (91.4%) | 0.004* | 3.587 (1.627–7.909) | 0.002* |
| (+) | 12(2.7%) | 7 (8.6%) | |||
| Less than 12 lymph nodes | |||||
| Yes | 76 (16.9%) | 21 (25.9%) | 0.583 | ||
| No | 373 (83.1%) | 60 (74.1%) | |||
| dMMR | |||||
| Positive | 14 (2.7%) | 7 (8.6%) | 0.021* | 2.848 (1.300–6.238) | 0.009* |
| Negative | 435 (97.3%) | 74 (91.4%) | |||