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Table 3 Univariate and multivariate analyses for disease free survival in stage I colorectal cancer

From: Survival after curative resection for stage I colorectal mucinous adenocarcinoma

Variable

Without recurrence (n = 449)

With recurrence (n = 81)

Univariate p value

Multivariate

    

HR (95% CI)

p value

Gender

     

 Male

241 (53.7%)

48 (59.3%)

0.268

  

 Female

208 (46.3%)

33 (40.7%)

   

Age

     

 ≤ 65

287 (63.9%)

44 (54.3%)

0.090

  

 > 65

162 (36.1%)

37 (45.7%)

   

Preoperative CEA

     

 ≤ 5

400 (89.1%)

66 (81.5%)

0.042*

1.863 (1.049–3.310)

0.034*

 > 5

49 (10.9%)

15 (18.5%)

   

T classification

     

 T1

149 (33.2%)

21 (25.9%)

0.243

  

 T2

300 (66.8%)

60 (74.1%)

   

Lesion location

     

 Colon

144 (32.1%)

16 (19.8%)

0.036*

1.813 (1.041–3.156)

0.035*

 Rectal

305 (67.9%)

65 (80.2%)

   

Size

     

 < 3 cm

260 (57.9%)

49 (60.5%)

0.527

  

 ≥ 3 cm

189 (42.1%)

32 (39.5%)

   

Mucinous histology

     

 MAC

48 (10.7%)

10 (12.3%)

0.746

  

 Non-MAC

401 (89.3%)

71 (87.7%)

   

LVI

     

 (−)

437 (97.3%)

74 (91.4%)

0.004*

3.587 (1.627–7.909)

0.002*

 (+)

12(2.7%)

7 (8.6%)

   

Less than 12 lymph nodes

     

 Yes

76 (16.9%)

21 (25.9%)

0.583

  

 No

373 (83.1%)

60 (74.1%)

   

dMMR

     

 Positive

14 (2.7%)

7 (8.6%)

0.021*

2.848 (1.300–6.238)

0.009*

 Negative

435 (97.3%)

74 (91.4%)

   
  1. The bold and *  indicates p < 0.05
  2. MAC mucinous adenocarcinomas, CEA carcinoembryonic antigen, dMMR deficient mismatch repair
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BMC Gastroenterology

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