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Table 1 Characteristics of patients in the training and validation dataset

From: Development and validation of a nomogram for prediction of cervical lymph node metastasis in middle and lower thoracic esophageal squamous cell carcinoma

Characteristic Training dataset Validation dataset P
Total Cervical LN Metastasis Total Cervical LN Metastasis
(−)
(n = 108)
(+)
(n = 36)
(−)
(n = 68)
(+)
(n = 23)
Gender, No. (%) 0.26
 Male 100 (69.4) 75 (69.4) 25 (69.4) 56 (61.6) 38 (55.9) 18 (78.3)  
 Female 44 (30.6) 33 (30.6) 11 (30.6) 35 (38.5) 30 (44.1) 5 (22.7)  
Age, median (IQR), years 62
(58.5, 65.5)
62.5
(58.5, 66)
61.5
(58, 64.5)
62
(58, 67)
62.5
(58.5, 67)
60
(54, 65)
0.69
Tumor location, No. (%) 0.75
 Middle 111 (77.1) 80 (74.1) 31 (86.1) 68 (74.7) 52 (76.5) 16 (69.6)  
 Lower 33 (22.9) 28 (25.9) 5 (13.9) 23 (25.3) 16 (23.5) 7 (30.4)  
Degree of differentiation, No. (%) 0.44
 Well 18 (12.5) 14 (13.0) 4 (11.1) 17 (18.7) 16 (23.5) 1 (4.3)  
 Moderate 85 (59.0) 62 (57.4) 23 (63.9) 51 (56.0) 37 (54.4) 14 (60.9)  
 Poorly 41 (28.5) 32 (29.6) 9 (25.0) 23 (25.3) 15 (22.1) 8 (34.8)  
Maximum diameter of tumor, median (IQR), cm 3.5
(2.5, 5)
3.5
(2.45,4.5)
4.25
(3, 5.75)
3
(2, 4)
3
(2, 4)
4
(3, 5)
0.12
Depth of tumor invasion, No. (%) 0.37
 T1 32 (22.2) 29 (26.9) 3 (8.3) 28 (30.8) 27 (39.7) 1 (4.3)  
 T2 23 (16.0) 18 (16.7) 5 (13.9) 17 (18.7) 15 (22.1) 2 (8.7)  
 T3 71 (49.3) 50 (46.3) 21 (58.3) 38 (41.8) 22 (32.4) 16 (69.6)  
 T4 18 (12.5) 11 (10.2) 7 (19.4) 8 (8.8) 4 (5.9) 4 (17.4)  
PLN status No. (%) 0.15
 Negative 115 (79.9) 94 (87.0) 21 (58.3) 80 (87.9) 64 (94.1) 16 (69.6)  
 Positive 29 (20.1) 14 (13.0) 15 (41.7) 11 (12.1) 4 (5.9) 7 (30.4)  
MLN status No. (%) 0.85
 Negative 122 (84.7) 97 (89.8) 25 (69.4) 76 (83.5) 64 (94.1) 12 (52.2)  
 Positive 22 (15.3) 11 (10.2) 11 (30.6) 15 (16.5) 4 (5.9) 11 (47.8)  
RLN LN status No. (%) 0.48
 Negative 93 (64.6) 80 (74.1) 13 (36.1) 63 (69.2) 55 (80.9) 8 (34.8)  
 Positive 51 (35.4) 28 (25.9) 23 (63.9) 28 (30.8) 13 (19.1) 15 (65.2)  
ALN status No. (%) 0.56
 Negative 99 (68.8) 75 (69.4) 24 (66.7) 66 (72.5) 56 (82.4) 10 (43.5)  
 Positive 45 (31.3) 33 (30.6) 12 (33.3) 25 (27.5) 12 (17.6) 13 (56.5)  
Blood vessel invasion, No. (%) 0.84
 Negative 128 (88.9) 99 (91.7) 29 (80.6) 80 (87.9) 64 (94.1) 16 (69.6)  
 Positive 16 (11.1) 9 (8.3) 7 (19.4) 11 (12.1) 4 (5.9) 7 (30.4)  
Nerve invasion, No. (%) 0.86
 Negative 121 (84.0) 93 (86.1) 28 (77.8) 75 (82.4) 59 (86.8) 16 (69.6)  
 Positive 23 (16.0) 15 (13.9) 8 (22.2) 16 (17.6) 9 (13.2) 7 (30.4)  
CT-reported cervical LN status, No. (%) 0.63
 Negative 113 (78.5) 91 (84.3) 22 (61.1) 69 (75.8) 55 (80.9) 14 (60.9)  
 Positive 31 (21.5) 17 (15.7) 14 (38.9) 22 (24.2) 13 (19.1) 9 (39.1)  
  1. LN lymph node, PLN paraoesophageal lymph node, MLN mediastinal lymph node, RLN LN recurrent laryngeal nerve lymph node, ALN abdominal lymph node