|  | Univariate | Multivariate | |||
---|---|---|---|---|---|---|
n | OS 5Â years | p valuea | Hazard ratio (95% CI) | p valueb | ||
Period | 07–13′/00–06′ | 95/98 | 37.8/21.3 | < 0.001 | 0.63 (0.41–0.95) | 0.026 |
Age (year) | ≥ 70/< 70 | 96/97 | 33.3/25.7 | 0.60 |  |  |
Sex | Female/male | 108/85 | 27.4/32.1 | 0.90 | Â | Â |
Preop. Jaundice | Yes/no | 63/128 | 12.1/38.0 | < 0.001 | 1.70 (1.02–2.86) | 0.044 |
NAC | Yes/no | 11/182 | 11.4/30.6 | 0.30 | Â | Â |
CA19-9, U/L | > 37/≤ 37 | 110/79 | 16.2/46.6 | < 0.001 | 1.25 (0.99–1.32) | 0.31 |
CEA, ng/mL | > 5/≤ 5 | 59/132 | 15.2/35.6 | 0.003 | 1.52 (0.81–1.94) | 0.054 |
Incidental | Yes/no | 19/174 | 9.59/31.3 | 0.08 | Â | Â |
Hepatectomy | Ch/GB | 34/47 | 34.9/39.5 | < 0.001 | 1.90 (0.95–3.82) | 0.071 |
 | S4aS5/GB | 42/47 | 39.2/39.5 |  | 1.21 (0.68–2.15) | 0.51 |
 | ≥ 3 seg/GB | 62/47 | 11.9/39.5 |  | 1.71 (0.93–3.13) | 0.082 |
BDR.PD | Absent/BDR | 58/107 | 38.7/24.1 | 0.06 | Â | Â |
 | PD/ BDR | 28/107 | 30.4/24.1 |  |  |  |
Blood loss, mL | ≥ 864/< 864 | 91/90 | 13.5/42.0 | < 0.001 | 1.33 (0.79–2.23) | 0.29 |
Surgery time, min | ≥ 366/< 366 | 91/90 | 18.2/37.9 | 0.001 | 1.08 (0.66–1.79) | 0.76 |
Histology | pap/tub1.2 | 23/129 | 50.2/27.0 | 0.02 | 0.59 (0.29–1.20) | 0.15 |
 | tub3/tub1.2 | 40/129 | 23.7/27.0 |  | 1.42 (0.84–2.38) | 0.19 |
AJCC T 8th | T2/T3 | 50/102 | 43.6/27.4 | < 0.001 | 1.30 (0.74–2.27) | 0.36 |
 | T4/T3 | 41/102 | 16.5/27.4 |  | 1.12 (0.65–1.95) | 0.67 |
AJCC N 8th | N0/N1 | 65/77 | 39.2/26.1 | 0.07 | Â | Â |
 | N2/N1 | 14/77 | 9.23/26.1 |  |  |  |
 | Distant/N1 | 37/77 | 25.0/26.1 |  |  |  |
H | H1/H0 | 12/167 | 30.1/46.3 | 0.03 | 1.03 (0.43–2.49) | 0.94 |
 | H2/H0 | 14/167 | 7.69/46.3 |  | 2.11 (1.06–4.21) | 0.035 |
P | P1.2/P0 | 16/177 | 0/32.2 | < 0.001 | 2.08 (1.05–4.12) | 0.036 |
Residual cancer | R1.2/R0 | 60/131 | 12.1/36.9 | < 0.001 | 1.29 (0.82–2.02) | 0.27 |
Morbidity* | ≥ 3/≤ 2 | 54/137 | 18.6/33.8 | 0.004 | 1.44 (0.94–2.22) | 0.097 |
AC | with /without | 86/98 | 32.8/28.5 | 0.30 | Â | Â |