Fig. 2

ROC curve of EVs and CA19-9. ROC curves are shown for CD63⁺-EVs (a), CD41⁺-EVs (b), CD61⁺-EVs (c), and CA19-9 (d). Area under curve (AUC) and its 95% confidence interval are indicated in the figure. Dot indicates the cut-off value which maximizes the sum of sensitivity and specificity