Effect of alcohol on clinical complications of hepatitis virus-induced liver cirrhosis: a consecutive ten-year study

Table 4 Univariate and multivariate logistic regression evaluating factors associated with EGVB in ALD, HBV and ALD + HBV patients

Factors	Without EGVB	With EGVB	ULR	MLR
Factors	n (%)	n (%)	P value	OR (95% CI)	P value
Sex (male)	4717 (85.5)	2282 (87.3)	0.026
Age (> 50y)	3288 (59.6)	1425 (54.5)	< 0.001
Etiologies			< 0.001
HBV	4622 (83.8)	1990 (76.1)		1
ALD	495 (9.0)	318 (12.2)		1.14 (0.81–1.59)	0.451
ALD + HBV	401 (7.3)	306 (11.7)		1.74 (1.30–2.33)	< 0.001
T2DM	644 (11.7)	252 (10.2)	0.060
Decomp. Sx	1914 (34.7)	2614 (100)	< 0.001
Infection	1060 (19.2)	690 (26.4)	< 0.001
Ascites	2835 (51.4)	1403 (53.7)	0.053	0.51 (0.41–0.64)	< 0.001
HE	226 (4.1)	218 (8.3)	< 0.001	1.44 (1.07–1.95)	0.018
Thrombus	449 (8.1)	276 (10.6)	< 0.001	1.35 (1.01–1.79)	0.039
HCC	2043 (37.0)	813 (31.1)	< 0.001	1.46 (1.19–1.78)	< 0.001
HRS	45 (0.80)	72 (2.8)	< 0.001	2.58 (1.54–4.32)	< 0.001
Child			< 0.001
A	2131 (39.2)	911 (36.4)		1
B	2317 (42.6)	1043 (41.7)		0.12 (0.08–0.19)	< 0.001
C	988 (18.2)	549 (21.9)		0.10 (0.07–0.16)
MCV > 100	753 (13.7)	255 (9.8)	< 0.001	0.69 (0.54–0.90)	0.006
ALT > 40	2650 (48.3)	1120 (43.3)	< 0.001
AST > 40	2500 (94.3)	1117 (92.4)	0.023
GGT > 60	1952 (74.1)	816 (69.4)	0.003

ULR, univariate logistic regression; MLR, multivariate logistic regression; HBV, hepatitis B virus; ALD, alcohol-induced liver disease; ALD + HBV, co-existing ALD and HBV; HCC, Hepatocellular carcinoma; T2DM, type 2 diabetes mellitus; Decomp. Sx., decompensation symptoms and signs; HE, Hepatic Encephalopathy; EGVB, Esophageal gastric variceal bleeding, HRS: Hepatorenal Syndrome; MCV > 100, ALT > 40, AST > 40, GGT > 60 represent proportion of patients with mean corpuscular volume, alanine aminotransferase, aspartate aminotransferase, Gamma-glutamyl transferase greater than 100, 40, 40, and 60 respectively

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