Table 1 Baseline characteristics of patients in the trials included in the meta-analysis
From: Characterization of short-chain fatty acids in patients with ulcerative colitis: a meta-analysis
Study | Country | Study design | Case/control (n) | Diagnostic criteria | Disease activity criteria | Disease extent | Method | NOS score |
|---|---|---|---|---|---|---|---|---|
Takaishi H [4] | Japan | Case–control | 39/10 | Clinical symptoms, laboratory data, and histology | At least 5 loose stools including obvious blood and visible inflammation at endoscopy | Proctitis, left-sided colitis, toal colitis | HPLC | 6 |
James SL [19] | Australia | Cohort | 14/10 | Standard criteria (No detail) | CAI > 5 [36] | Proctitis, distal colitis, extensive colitis | HPLC | 6 |
Machiels K [20] | Belgium | Case–control | 127/87 | NA | Partial Mayo Score ≥ 2 | Proctitis, left-sided colitis, pancolitis | GC/MS | 7 |
Roediger WEW [21] | UK | Case–control | 64/16 | Endoscopy and histology | Mild/moderate/severe activity in the mucosa or inflammatory change on biopsy [37] | NA | GC | 6 |
Kumari R [22] | India | Case–control | 11/10 | NA | Clinical colitis activity index > 3 [38] | Proctitis, left-sided colitis, pancolitis | GC/FID | 6 |
Marchesi JR [23] | Ireland | Case–control | 10/13 | Clinical symptoms, laboratory data, and histopathology | NA | NA | High resolution H NMR spectroscopy | 6 |
Hove H [24] | Denmark | Case–control | 42/20 | NA | NA | NA | GLC | 6 |
Bjerrum JT [25] | Denmark | Case–control | 44/21 | Well-established criteria [39] | Partial Mayo Score ≥ 2 | Proctitis, proctosigmoiditis, left-sided Colitis, pancolitis | H NMR spectroscopy | 6 |
Vernia P [26] | Italy | Case–control | 18/16 | Radiographically and/or endoscopy | NA | NA | GLC | 6 |
Vernia P [27] | Italy | Case–control | 62/29 | Clinical, radiologic, endoscopic, and histologic findings | Criteria of Truelove and Witts [40] | Total colitis, left-sided colitis, proctosigmoiditis | GLC | 7 |
Treem WR [28] | USA | Case–control | 17/12 | Standard clinical, radiologic, endoscopic, and histologic criteria | Criteria of Truelove and Witts | NA | GLC | 6 |