Table 1 Prognostic factors associated with RFS by Cox proportional hazards regression model

Age (years old)

1.02 (1.00–1.03)

0.006

1.02 (1.00–1.03)

0.008

Sex (male/female)

1.61 (1.25–2.08)

 < 0.001

1.70 (1.30–2.22)

 < 0.001

Hypertension (yes/no)

0.99 (0.79–1.23)

0.907

Diabetes mellitus (yes/no)

1.08 (0.85–1.37)

0.545

Smoking history (yes/no)

1.17 (0.97–1.41)

0.094

Drinking history (yes/no)

1.14 (0.94–1.38)

0.202

Antivival history (yes/no)

0.87 (0.72–1.05)

0.151

Etiology (HBV/HCV/Co-infection/others)

0.99 (0.90–1.09)

0.791

Cirrhosis (yes/no)

1.36 (1.04–1.77)

0.023

1.36 (1.02–1.81)

0.036

Child–Pugh class (A/B)

1.20 (0.96–1.48)

0.084

Fractional ablation (yes/no)

1.52 (1.18–1.97)

0.001

0.92 (0.68–1.24)

0.571

Ablative modality (RFA/MWA/AHC)

0.94 (0.84–1.05)

0.300

Tumor number (single/multiple)

1.58 (1.30–1.91)

 < 0.001

1.61 (1.30–1.99)

 < 0.001

Tumor size (≤ 30 mm/ > 30 mm)

1.74 (1.43–2.11)

 < 0.001

1.61 (1.29–2.01)

 < 0.001

Alanine aminotransferase (U/L)

1.00 (0.99–1.01)

0.302

Aspartate aminotransferase (U/L)

1.01 (1.00–1.01)

0.001

1.01 (1.00–1.01)

0.012

Total bilirubin (μmol/L)

1.01 (1.00–1.02)

0.023

1.00 (0.99–1.01)

0.691

Albumin (g/l)

0.96 (0.94–0.98)

 < 0.001

0.99 (0.96–1.02)

0.437

INR

2.37 (1.14–4.91)

0.021

1.16 (0.41–3.30)

0.779

Alpha fetoprotein (< 7/7–400/ > 400 ng/mL)

1.22 (1.06–1.41)

0.007

1.15 (0.98–1.34)

0.091

Viral load (< 1000/1000–20,000/ > 20000 IU/mL)

1.14 (1.02–1.28)

0.019

1.03 (0.91–1.16)

0.648

NLR

1.03 (0.98–1.06)

0.077

PLR

1.00 (1.00–1.00)

0.109

MLR

1.99 (1.36–2.91)

 < 0.001

1.65 (1.08–2.53)

0.022