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Table 1 Clinicopathological characteristics of patients with SCRC and PCRC

From: Clinicopathologic characteristics and prognosis of synchronous colorectal cancer: a retrospective study

  Overall SCRC PCRC P valueb
N = 1554 N = 422 N = 1132
Sex (%)
 Female 564 (36.29) 126 (29.86) 438 (38.69) 0.002
 Male 990 (63.71) 296 (70.14) 694 (61.31)
EOCRC or LOCRC (%)
 LOCRC 1233 (79.34) 358 (84.83) 875 (77.30) 0.001
 EOCRC 321 (20.66) 64 (15.17) 257 (22.70)
Age (yrs) (median [IQR]) 61.00 [52.00, 68.00] 63.00 [55.00, 70.75] 60.00 [51.00, 68.00] < 0.001a
Family history of tumours (%)
 No 1497 (96.33) 399 (94.55) 1098 (97.00) 0.033
 Yes 57 (3.67) 23 (5.45) 34 (3.00)
BMI (kg/m2) (%)
 18.5 to 24 927 (59.65) 252 (59.72) 675 (59.63) 0.364
 < 18.5 152 (9.78) 48 (11.37) 104 (9.19)
 ≥ 24 475 (30.57) 122 (28.91) 353 (31.18)
Hemoglobin (g/L) (%)
 > 110 1063 (68.40) 259 (61.37) 804 (71.02) < 0.001
 ≤ 100 491 (31.60) 163 (38.63) 328 (28.98)
Platelet counts (109/L) (%)
 ≤ 300 1122 (72.20) 289 (68.48) 833 (73.59) 0.053
 > 300 432 (27.80) 133 (31.52) 299 (26.41)
WBC (109/L) (%)
 ≤ 10 1441 (92.73) 388 (91.94) 1053 (93.02) 0.537
 > 10 113 (7.27) 34 (8.06) 79 (6.98)
CEA (ng/mL) (%)
 ≤ 10 1157 (74.45) 297 (70.38) 860 (75.97) 0.029
 > 10 397 (25.55) 125 (29.62) 272 (24.03)
CA199 (kU/L) (%)
 ≤ 27 1225 (78.83) 320 (75.83) 905 (79.95) 0.090
 > 27 329 (21.17) 102 (24.17) 227 (20.05)
CA125 (kU/L) (%)
 ≤ 35 1428 (91.89) 383 (90.76) 1045 (92.31) 0.371
 > 35 126 (8.11) 39 (9.24) 87 (7.69)
CA153 (kU/L) (%)
 ≤ 25 1526 (98.20) 415 (98.34) 1111 (98.14) 0.965
 > 25 28 (1.80) 7 (1.66) 21 (1.86)
AFP (ng/mL) (%)
 ≤ 7 1488 (95.75) 402 (95.26) 1086 (95.94) 0.656
 > 7 66 (4.25) 20 (4.74) 46 (4.06)
Type of ascites (%)
 No 1453 (93.50) 389 (92.18) 1064 (93.99) 0.398
 Serous 90 (5.79) 30 (7.11) 60 (5.30)
 Bloody 11 (0.71) 3 (0.71) 8 (0.71)
Tumor location (%)
 Right colon 321 (20.66) 81 (19.19) 240 (21.20) < 0.001
 Left colon 436 (28.06) 93 (22.04) 343 (30.30)
 Rectum 659 (42.41) 110 (26.07) 549 (48.50)
 Multiple segment 138 (8.88) 138 (32.70) 0 (0.00)
Radical or palliative surgery (%)
 Palliative 185 (11.90) 61 (14.45) 124 (10.95) 0.071
 Radical 1369 (88.10) 361 (85.55) 1008 (89.05)
(y)pTNM staging (%)
 0–I 205 (13.19) 51 (12.09) 154 (13.60) 0.001
 II 572 (36.81) 130 (30.81) 442 (39.05)
 III 533 (34.30) 152 (36.02) 381 (33.66)
 IV 244 (15.70) 89 (21.09) 155 (13.69)
Number of retrieved lymph nodes (%)
 < 12 165 (10.62) 26 (6.16) 139 (12.28) 0.001
 ≥ 12 1389 (89.38) 396 (93.84) 993 (87.72)
Gross classification (%)    
 Mass type 583 (37.52) 168 (39.81) 415 (36.66) 0.138
 Infiltration type 13 (0.84) 6 (1.42) 7 (0.62)
 Ulceration type 958 (61.65) 248 (58.77) 710 (62.72)
Histological type (%)
 Classical adenocarcinoma 1452 (93.44) 391 (92.65) 1061 (93.73) 0.663
 Mucinous adenocarcinoma 97 (6.24) 29 (6.87) 68 (6.01)
 Signet ring cell carcinoma 5 (0.32) 2 (0.47) 3 (0.27)
Differentiation grade (%)
 Well differentiated 230 (14.80) 59 (13.98) 171 (15.11) 0.404
 Moderately differentiated 1096 (70.53) 293 (69.43) 803 (70.94)
 Poorly differentiated 228 (14.67) 70 (16.59) 158 (13.96)
Vessel invasion (%)
 Negative 1294 (83.27) 339 (80.33) 955 (84.36) 0.069
 Positive 260 (16.73) 83 (19.67) 177 (15.64)
Neural invasion (%)
 Negative 1243 (79.99) 339 (80.33) 904 (79.86) 0.892
 Positive 311 (20.01) 83 (19.67) 228 (20.14)
Ki67 expression (%)
 Low 95 (6.11) 28 (6.64) 67 (5.92) 0.616
 Moderate 204 (13.13) 60 (14.22) 144 (12.72)
 High 1255 (80.76) 334 (79.15) 921 (81.36)
MMR status (%)
 pMMR 1424 (91.63) 370 (87.68) 1054 (93.11) 0.001
 dMMR 130 (8.37) 52 (12.32) 78 (6.89)
Alive status (%)
 Alive 1293 (83.20) 338 (80.09) 955 (84.36) 0.054
 Death 261 (16.80) 84 (19.91) 177 (15.64)
  1. aIndependent samples Mann–Whitney U test; bThe bolded P value was statistically significant (P < 0.05)