|
Variables
|
Full sample (n = 71,633)
|
Matched sample (n = 29,974) a
|
|---|
|
H. pylori− (n = 46,888)
|
H. pylori + (n = 24,745)
|
P value
|
H. pylori− (n = 14,987)
|
H. pylori + (n = 14,987)
|
P value
|
|---|
|
Age
|
44.8 ± 13.3
|
46.5 ± 12.5
|
< 0.001
|
47.3 ± 12.9
|
46.6 ± 12.2
| |
|
Male (%)
|
57.6
|
58.6
|
0.010
|
58.3
|
57.5
|
0.134
|
|
BMI (kg/m2)
|
23.8 ± 3.4
|
24.1 ± 3.4
|
< 0.001
|
24.3 ± 3.3
|
24.2 ± 3.4
|
0.043
|
|
Year of screening exam (%)
| |
< 0.001
| | | |
|
2015
|
20.8
|
21.7
| |
21.6
|
12.6
| |
|
2016
|
24.4
|
24.2
| |
48.1
|
27.1
| |
|
2017
|
19.3
|
18.7
| |
25.1
|
23.0
| |
|
2018
|
19.8
|
21.3
| |
4.8
|
24.5
| |
|
2019
|
18.8
|
17.3
| |
0.4
|
12.7
| |
|
Systolic BP (mmHg)
|
124.3 ± 19.5
|
125.9 ± 20.0
|
< 0.001
|
127.1 ± 19.8
|
126.4 ± 20.0
| |
|
Diastolic BP (mmHg)
|
77.8 ± 11.4
|
78.9 ± 11.8
|
< 0.001
|
79.7 ± 11.5
|
79.1 ± 11.8
| |
|
Hypertension (%)
|
13.7
|
15.1
|
< 0.001
|
13.5
|
13.9
|
0.129
|
|
FBG (mM)
|
5.05 ± 1.27
|
5.18 ± 1.47
|
< 0.001
|
5.11 ± 1.29
|
5.12 ± 1.29
| |
|
HbA1C (%)
|
5.48 ± 0.75
|
5.55 ± 0.83
|
< 0.001
|
5.50 ± 0.77
|
5.50 ± 0.77
| |
|
Diabetes (%)
|
4.74
|
6.14
|
< 0.001
|
5.49
|
5.60
|
0.565
|
|
Total cholesterol (mM)
|
4.80 ± 0.92
|
4.86 ± 0.92
|
< 0.001
|
4.89 ± 0.91
|
4.86 ± 0.92
| |
|
LDL-C (mM)
|
2.76 ± 0.77
|
2.82 ± 0.78
|
< 0.001
|
2.22 ± 0.77
|
2.82 ± 0.77
| |
|
HDL-C (mM)
|
1.43 ± 0.34
|
1.41 ± 0.34
|
< 0.001
|
1.46 ± 0.35
|
1.41 ± 0.35
| |
|
Triglycerides (mM)
|
1.58 ± 1.39
|
1.65 ± 1.50
|
< 0.001
|
1.65 ± 1.41
|
1.64 ± 1.44
| |
|
Dyslipidemia (%)
|
24.9
|
28.0
|
< 0.001
|
26.8
|
26.9
|
0.887
|
|
AST (IU/L)
|
23.3 (18–25)
|
23.4 (18–25)
|
0.011
|
22.7 (17–25)
|
23.3 (18–26)
| |
|
ALT (IU/L)
|
26.5 (15–31)
|
27.0 (15–31)
|
< 0.001
|
27.4 (15–32)
|
27.0 (15–31)
| |
|
GGT (IU/L)
|
30.2 (14–33)
|
31.0 (15–35)
|
< 0.001
|
32.6 (15–36)
|
30.5 (14–35)
| |
|
Scr (μM)
|
70.5 ± 17.2
|
71.1 ± 20.1
|
0.001
|
69.6 ± 18.6
|
70.2 ± 17.6
| |
|
BUN (mM)
|
4.88 ± 1.30
|
4.95 ± 1.37
|
< 0.001
|
4.99 ± 1.32
|
4.94 ± 1.32
| |
|
NAFLD (%)
|
31.3
|
34.8
|
< 0.001
|
34.8
|
34.6
|
0.716
|
- Continuous variables were shown as mean ± SD or median (interquartile range), and categorical variables were expressed as counts (percentage)
- aMatched sample were selected with propensity score matching analysis (PSM) (Covariate: Age, sex, BMI, Systolic BP, Diastolic BP, FBG, HbA1C, Total cholesterol, LDL-C, HDL-C, Triglycerides, Scr, BUN; Matching tolerance: 0.001)
- H. pylori, Helicobacter pylori; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; HbA1C, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; Scr, serum creatinine; BUN, blood urea nitrogen; NAFLD, nonalcoholic fatty liver disease
