Fig. 3From: Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD studyStudy design of the AGAINST-PLD study. Patients are randomized between direct and delayed start (after 18Â months) of treatment. a Historical scan, b baseline scan, a, b historical growth. Primairy outcome, comparison between growth on treatment and without treatment in the first 18Â months is b, c versus b, e. Secondary outcome, growth within individuals before and during treatment is b, c versus c, d and a, b versus b, eBack to article page