Skip to main content

Table 2 Univariate Cox regression analysis

From: The fate of indeterminate liver lesions: What proportion are precursors of hepatocellular carcinoma?

Covariate

Continuous/Categorical

Hazard ratio

95% CI

P value

Data available (N)

Sex

Categorical

Female

Reference

109

Male

1.444

0.568–3.667

0.440

Age at diagnosis

Continuous

 

1.015

0.982–1.050

0.377

109

BMI

Continuous

 

0.994

0.913–1.082

0.889

92

Categorical

Normal BMI

Reference

Overweight or obese

1.062

0.403–2.796

0.903

Smoking status

Categorical

Non-smoker

Reference

107

Smoker or ex-smoker

2.308

0.936–5.694

0.069

Non-smoker or ex-smoker

Reference

Smoker

2.027

0.796–5.161

0.138

Alcohol use

Categorical

14 units or less per week

Reference

106

More than 14 units per week

3.117

1.121–8.672

0.029

Platelet count

Continuous

 

0.982

0.972–0.992

 < 0.001

106

Categorical

Normal range

Reference

Below LLN

7.259

2.114–24.920

0.002

ALT*

Continuous

 

1.099

0.646–1.872

0.728

106

Categorical

Normal range

Reference

Above ULN

1.291

0.508–3.280

0.591

AST*

Continuous

 

1.460

0.734–2.904

0.281

106

Categorical

Normal range

Reference

Above ULN

1.747

0.702–4.343

0.230

ALP*

Continuous

 

1.406

0.518–3.816

0.504

106

Categorical

Normal range

Reference

Above ULN

1.406

00.518–3.816

0.504

Albumin

Continuous

 

0.914

0.852–0.981

0.013

106

Categorical

Normal range

Reference

Below LLN

1.632

0.217–12.266

0.634

AFP*

Continuous

 

1.433

0.958–2.144

0.080

97

Categorical

Normal range

Reference

Above ULN

2.715

1.042–7.074

0.041

Largest index lesion diameter

Categorical

Less than 1 cm versus 1 cm or more

Reference

93

1.296

0.493–3.406

0.599

Less than 2 cm versus 2 cm or more

Reference

0.790

0.227–2.753

0.712

  1. Estimates of association with HCC are presented as hazard ratios for each covariate
  2. CI, confidence intervals; BMI, body mass index; LLN, lower limit of normal; ALT, alanine aminotransferase; ULN, upper limit of normal; AST, aspartate aminotransferase; ALP, alkaline phosphatase; AFP, alphafetoprotein
  3. *Data were positively skewed, therefore transformed by the natural logarithm before regression analysis as a continuous variable
  4. P values in bold represent statistically significant values at the 0.05 level
Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us