Fig. 4

Proteomic analysis of S180 cells treated with DMSO or 5 μM MS275 respectively for 48 h. A Proteomic analysis of upregulated and downregulated protein in S180 cells treated with DMSO or MS275. B Volcano plots showing differentially distributed proteins comparing DMSO control and MS275 treated group. Proteins represented by red dots indicate upregulation, and green dots indicate downregulated proteins (p < 0.05, ratio > 1.5 or < 0.667). C Hierarchical clustering of the differentially distributed proteins identified from each group (ratio > 1.5 or < 0.667). The color scale indicates the expression level of each protein across the two groups