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Table 5 General characteristics of the patients by ferritin level

From: Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis

Variables

Ferritin ≤ 199 (μg/L) (n = 46)

Ferritin > 199 (μg/L) (n = 51)

P

Age (years)

49.6 ± 11.7

57.9 ± 9.4

 < 0.001

Female, n (%)

41 (89.1)

41 (80.4)

0.235

Autoantibodies positive, n (%)

38 (82.6)

45 (88.2)

0.431

IgG (g/L)

16.50 (13.38, 21.80)

16.80 (12.90, 21.00)

0.694

ALT (U/L)

50.0 (23.0, 152.8)

124.0 (44.0, 482.0)

0.006

AST (U/L)

64.0 (28.0, 179.3)

209.0 (47.0, 542.0)

0.003

ALP (U/L)

101.0 (78.8, 148.0)

118.0 (72.0, 151.0)

0.549

GGT (U/L)

110.5 (63.5, 174.3)

147.0 (56.0, 301.0)

0.116

TBIL (μmol/L)

15.4 (11.7, 32.2)

25.4 (14.6, 133.7)

0.009

ALB (g/L)

41.1 ± 5.6

39.3 ± 5.5

0.106

PLT (× 109/L)

195.4 ± 79.4

175.3 ± 60.5

0.162

PT (s)

12.9 ± 1.3

13.4 ± 1.6

0.09

Iron (μmol/L)

21.0 ± 12.1

33.7 ± 13.7

 < 0.001

Transferrin (g/L)

3.04 (2.41, 3.40)

2.41 (2.13, 2.88)

0.001

UIBC (μmol/L)

45.0 (30.2, 58.6)

24.6 (12.5, 32.0)

 < 0.001

TIBC (μmol/L)

64.9 (54.9, 75.4)

56.6 (53.6, 66.9)

0.022

TSI (%)

30.9 (19.1, 50.2)

56.9 (43.3, 80.8)

 < 0.001

Histology (inflammation), n (%)

  

 < 0.001

 G1

2 (4.3)

1 (2.0)

 

 G2

30 (65.2)

12 (23.5)

 

 G3

12 (26.1)

28 (54.9)

 

 G4

2 (4.3)

10 (19.6)

 

Histology (fibrosis), n (%)

  

0.001

 F0

10 (21.7)

1 (2.0)

 

 F1

13 (28.3)

9 (17.6)

 

 F2

14 (30.4)

12 (23.5)

 

 F3

5 (10.9)

16 (31.4)

 

 F4

4 (8.7)

13 (25.5)

 
  1. Data are expressed as mean (± standard deviation), median (quartile 25, quartile 75) or number (proportion)
  2. IgG immunoglobulin G, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gamma-glutamyl transpeptidase, TBIL total bilirubin, ALB albumin, PLT platelet, PT prothrombin time, UIBC unsaturated iron binding capacity, TIBC total iron binding capacity, TSI transferrin saturation index