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Table 5 General characteristics of the patients by ferritin level

From: Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis

Variables Ferritin ≤ 199 (μg/L) (n = 46) Ferritin > 199 (μg/L) (n = 51) P
Age (years) 49.6 ± 11.7 57.9 ± 9.4  < 0.001
Female, n (%) 41 (89.1) 41 (80.4) 0.235
Autoantibodies positive, n (%) 38 (82.6) 45 (88.2) 0.431
IgG (g/L) 16.50 (13.38, 21.80) 16.80 (12.90, 21.00) 0.694
ALT (U/L) 50.0 (23.0, 152.8) 124.0 (44.0, 482.0) 0.006
AST (U/L) 64.0 (28.0, 179.3) 209.0 (47.0, 542.0) 0.003
ALP (U/L) 101.0 (78.8, 148.0) 118.0 (72.0, 151.0) 0.549
GGT (U/L) 110.5 (63.5, 174.3) 147.0 (56.0, 301.0) 0.116
TBIL (μmol/L) 15.4 (11.7, 32.2) 25.4 (14.6, 133.7) 0.009
ALB (g/L) 41.1 ± 5.6 39.3 ± 5.5 0.106
PLT (× 109/L) 195.4 ± 79.4 175.3 ± 60.5 0.162
PT (s) 12.9 ± 1.3 13.4 ± 1.6 0.09
Iron (μmol/L) 21.0 ± 12.1 33.7 ± 13.7  < 0.001
Transferrin (g/L) 3.04 (2.41, 3.40) 2.41 (2.13, 2.88) 0.001
UIBC (μmol/L) 45.0 (30.2, 58.6) 24.6 (12.5, 32.0)  < 0.001
TIBC (μmol/L) 64.9 (54.9, 75.4) 56.6 (53.6, 66.9) 0.022
TSI (%) 30.9 (19.1, 50.2) 56.9 (43.3, 80.8)  < 0.001
Histology (inflammation), n (%)     < 0.001
 G1 2 (4.3) 1 (2.0)  
 G2 30 (65.2) 12 (23.5)  
 G3 12 (26.1) 28 (54.9)  
 G4 2 (4.3) 10 (19.6)  
Histology (fibrosis), n (%)    0.001
 F0 10 (21.7) 1 (2.0)  
 F1 13 (28.3) 9 (17.6)  
 F2 14 (30.4) 12 (23.5)  
 F3 5 (10.9) 16 (31.4)  
 F4 4 (8.7) 13 (25.5)  
  1. Data are expressed as mean (± standard deviation), median (quartile 25, quartile 75) or number (proportion)
  2. IgG immunoglobulin G, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gamma-glutamyl transpeptidase, TBIL total bilirubin, ALB albumin, PLT platelet, PT prothrombin time, UIBC unsaturated iron binding capacity, TIBC total iron binding capacity, TSI transferrin saturation index