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Table 2 Comparison of undifferentiated embryonal sarcoma of the liver, hepatoblastoma, mesenchymal hamartoma and embryonal rhabdomyosarcoma

From: A large undifferentiated sarcoma of the liver in a 13-year-old girl treated with anatomical resection: a case report and review of the literature

Type of tumor Radiological appearance Clinical manifestations Pathology Immunohistochemistry Location
UESL Solid (USG), cystic mass with internal septations and serpiginous vessels (CT), hypointense (T1-weighted MRI), hyperintense (T2 MRI) Abdominal pain, palpable mass, fever Spindle and stellate pleomorphic cells in a myxoid stroma Vimentin, α1-antitrypsin, CD10, CD56, CD68, BCL2 Solitary mass in the right lobe of the liver
Hepatoblastoma Sometimes with lesion and hemorrhage in the mass (USG), attenuation values
Between water and normal liver parenchyma (CT), bands with low signal intensity compared with liver (T1-weighted MRI), bands with high signal intensity compared with liver (T2-weighted MRI)
Abdominal distension, abdominal mass Various histological subtypes in different stages of liver development CK19, beta-catenin, epcam Mostly, a solitary mass in the right lobe of the liver
Mesenchymal hamartoma Cystic mass with internal septations (USG), cystic mass with septal and solid stromal enhancement (CT/MRI), variable intensity (T1-weighted MRI), high signal intensity (T2-weighted MRI) Abdominal distension, abdominal mass Lobular growth of myxomatous connective tissue with branching bile ducts Vimentin, α1-antitrypsin, actin, cytokeratin, desmin Usually, a large solitary mass in the right lobe of the liver
Embryonal rhabdomyosarcoma Dilation of the intra- and extrahepatic bile ducts with an intraductal mass (USG), signal of skeletal muscle (T1-weighted MRI), hyperintense (T2-weighted MRI) Jaundice, abdominal pain, fever, vomiting A condensed layer of neoplastic subepithelial cellularity (cambium layer) Desmin, myogenin, Myo-D1 Biliary tract
  1. UESL undifferentiated embryonal sarcoma of the liver, USG ultrasonography, CT computed tomography, MRI magnetic resonance imaging