Unresectable primary hepatic adenosquamous carcinoma successfully treated with systemic and transcatheter hepatic arterial injection chemotherapies followed by conversion surgery: a case report and literature review

Table 2 Summary of 19 cases in which chemotherapy was used for treatment

No.	Regimen	Object	Administration route	Response	Prognosis	References
1	5-FU + CDDP	Adj	Intravenously	NR	Alive, 8 months after surgery	[27]
2	GEM + S-1	Adj	Intravenously	NR	Alive, 8 months after surgery	[37]
3	5-FU	Adj	Intravenously	NR	Alive, 15 months after surgery	[21]
4	Capecitabine	Adj	Oral	NR	Alive, 15 months after surgery	[46]
5	Sorafenib	Adj	Oral	NR	Alive, 7 months after surgery	[46]
6	Capecitabine	Adj	Oral	R	Dead	[46]
7	contents unknown	Adj	n.a	R	Dead, 8 months after surgery	[19]
8	contents unknown	Chemo	n.a	PD	Dead	[20]
9	contents unknown	Chemo	n.a	PD	Dead	[46]
10	contents unknown	Chemo	n.a	PD	Dead	[46]
11	contents unknown	Chemo	n.a	PD	Dead	[46]
12	5-FU + CDDP	Chemo	TAI	PD	Dead, 14 months after diagnosis	[45]
13	5-FU + CDDP	Chemo	TAI	PD	Dead, 13 months after diagnosis	[36]
14	GEM + CDDP	Chemo	Intravenously	PD	Dead	[39]
15	GEM + S-1	Chemo	Intravenously	PD	Dead, 10 months after surgery	[17]
16	5-FU + CDDP	Chemo	TAI	PR	Alive, 8 months after chemo	[28]
17	5-FU + CDDP	Chemo	TAI	PR	Alive, 8 months after chemo	[29]
18	GEM + CDDP	Chemo	Intravenously	PR	Alive, 11 months after surgery	[41]
19	S-1 + CDDP	Conversion therapy	TAI	PR	Alive, 6 months after surgery	Our case

Adj, Adjuvant chemotherapy; Cx, Chemotherapy; CDDP, cisplatin; GEM, gemcitabine; n.a., not applicable; No., number; NR, no recurrence; PD, progressive disease; PR, partial remission; R, recurrence; Ref, Reference; S-1, Tegafur/Gimeracil/Oteracil; TAI, transcatheter hepatic arterial injection; 5-FU, 5-fluorouracil

ISSN: 1471-230X