Table 5 Association of the ABCG8 rs11887534 variant and hormone use with gallstones in the female study participants

ABCG8 rs11887534 genotype, hormone use

 ABCG8 rs11887534 GG, no hormone use (reference)

–

–

–

–

 ABCG8 rs11887534 GG, hormone use

1.333

1.082

1.643

0.0069

 ABCG8 rs11887534 GC + CC, no hormone use

1.644

1.061

2.548

0.0261

 ABCG8 rs11887534 GC + CC, hormone use

3.596

1.495

8.650

0.0043

Menopause

 No (reference)

–

–

–

–

 Yes

1.251

0.935

1.674

0.1312

Age

1.042

1.027

1.058

< .0001

Regular exercise

 No (reference)

–

–

–

–

 Yes

0.816

0.682

0.975

0.0256

Cigarette smoking

 No (reference)

–

–

–

–

 Yes

1.237

0.823

1.861

0.3068

Alcohol drinking

 No (reference)

–

–

–

–

 Yes

1.322

0.790

2.214

0.2885

BMI

 Normal (reference)

–

–

–

–

 Underweight

0.900

0.518

1.564

0.7084

 Overweight

1.312

1.073

1.605

0.0081

 Obesity

1.189

0.930

1.519

0.1667

Family history of gallstones

 No (reference)

–

–

–

–

 Yes

1.733

1.334

2.251

< .0001

Diabetes

 No (reference)

–

–

–

–

 Yes

1.052

0.804

1.378

0.7115

Total bilirubin

1.884

1.355

2.619

0.0002

AST

0.986

0.972

1.001

0.0710

ALT

1.011

1.002

1.021

0.0214

HDL-C (mg/dL)

0.988

0.981

0.996

0.0019

LDL-C (mg/dL)

0.997

0.994

0.999

0.0120

TG (mg/dL)

1.000

0.999

1.001

0.7689

Dietary fat score

1.005

0.995

1.014

0.3356