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Table 5 Association of the ABCG8 rs11887534 variant and hormone use with gallstones in the female study participants

From: Risk of gallstones based on ABCG8 rs11887534 single nucleotide polymorphism among Taiwanese men and women

Variables OR 95% CI P-value
ABCG8 rs11887534 genotype, hormone use     
 ABCG8 rs11887534 GG, no hormone use (reference)
 ABCG8 rs11887534 GG, hormone use 1.333 1.082 1.643 0.0069
 ABCG8 rs11887534 GC + CC, no hormone use 1.644 1.061 2.548 0.0261
 ABCG8 rs11887534 GC + CC, hormone use 3.596 1.495 8.650 0.0043
Menopause     
 No (reference)
 Yes 1.251 0.935 1.674 0.1312
Age 1.042 1.027 1.058 < .0001
Regular exercise     
 No (reference)
 Yes 0.816 0.682 0.975 0.0256
Cigarette smoking     
 No (reference)
 Yes 1.237 0.823 1.861 0.3068
Alcohol drinking     
 No (reference)
 Yes 1.322 0.790 2.214 0.2885
BMI     
 Normal (reference)
 Underweight 0.900 0.518 1.564 0.7084
 Overweight 1.312 1.073 1.605 0.0081
 Obesity 1.189 0.930 1.519 0.1667
Family history of gallstones     
 No (reference)
 Yes 1.733 1.334 2.251 < .0001
Diabetes     
 No (reference)
 Yes 1.052 0.804 1.378 0.7115
Total bilirubin 1.884 1.355 2.619 0.0002
AST 0.986 0.972 1.001 0.0710
ALT 1.011 1.002 1.021 0.0214
HDL-C (mg/dL) 0.988 0.981 0.996 0.0019
LDL-C (mg/dL) 0.997 0.994 0.999 0.0120
TG (mg/dL) 1.000 0.999 1.001 0.7689
Dietary fat score 1.005 0.995 1.014 0.3356
  1. OR odds ratio, CI confidence interval, ABCG8 ATP-binding cassette subfamily G Member 8, BMI body mass index, AST aspartate aminotransferase, ALT alanine transaminase, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride