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Table 1 Baseline characteristics of the derivation cohort and validation cohort

From: Development and validation of the nomogram based on INR and eGFR for estimation of mortality in patients with acute-on-chronic hepatitis B liver failure

Variables

Derivation cohort (n = 75)

Validation cohort (n = 30)

P

Gender (%)

   

 Male/female

19/56

6/24

0.740

Age

49.03 ± 11.70

44.97 ± 12.68

0.140

Pathologic basis (%)

   

 CHB

53 (70.67%)

18 (60%)

 

 HBC

22 (29.33%)

12 (40%)

0.410

ALB (g/L)

31.61 ± 5.13

31.46 ± 5.35

0.930

TBIL (umol/L)

314.38 ± 104.00

328.73 ± 147.91

0.980

Na (mmol/L)

136.48 ± 3.94

135.01 ± 4.59

0.140

Cr (umol/L)

84.89 ± 61.13

80.05 ± 33.36

0.530

BUN (mmol/L)

6.33 ± 5.40

5.86 ± 2.59

0.480

CHE (U/L)

4012.60 ± 1506.31

3936.47 ± 1735.93

0.800

eGFR (ml/min)

98.03 ± 30.37

100.57 ± 32.53

0.720

INR

2.53 ± 1.31

2.72 ± 0.98

0.098

Lactate

2.10 ± 1.58

2.30 ± 1.26

0.260

MAP

84.11 ± 10.70

85.90 ± 10.11

0.260

HBV-DNA

7.70E + 04 (2.04E + 03,6.75E + 07)

2.39E + 05 (2.63E + 04,1.08E + 08)

0.120

HE

   

 Yes/no

16/59

7/23

1.000

Ascite

   

 Yes/no

71/4

30/0

0.470

AKI

   

 Yes/no

13/62

7/23

0.479

MELD score

24.81 ± 6.68

26.10 ± 5.68

0.355

AARC score

8.68 ± 1.85

9.27 ± 1.82

0.143

ALBI score

− 1.04 ± 0.45

− 1.04 ± 0.44

0.830

  1. CHB, chronic hepatitis B; HBC, hepatitis B cirrhosis; ALB, albumin; TBIL, total bilirubin; Na, serum sodium; Cr, creatinine; BUN, blood urea nitrogen; CHE, cholinesterase; eGFR, estimated glomerular filtration rate; INR, international normalized ratio; MAP, mean arterial pressure; HE, hepatic encephalopathy; AKI, acute renal injury; MELD, model for end-stage liver disease; AARC, APASL ACLF research consortium; ALBI, albumin-bilirubin