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Table 1 Baseline characteristics of the derivation cohort and validation cohort

From: Development and validation of the nomogram based on INR and eGFR for estimation of mortality in patients with acute-on-chronic hepatitis B liver failure

Variables Derivation cohort (n = 75) Validation cohort (n = 30) P
Gender (%)    
 Male/female 19/56 6/24 0.740
Age 49.03 ± 11.70 44.97 ± 12.68 0.140
Pathologic basis (%)    
 CHB 53 (70.67%) 18 (60%)  
 HBC 22 (29.33%) 12 (40%) 0.410
ALB (g/L) 31.61 ± 5.13 31.46 ± 5.35 0.930
TBIL (umol/L) 314.38 ± 104.00 328.73 ± 147.91 0.980
Na (mmol/L) 136.48 ± 3.94 135.01 ± 4.59 0.140
Cr (umol/L) 84.89 ± 61.13 80.05 ± 33.36 0.530
BUN (mmol/L) 6.33 ± 5.40 5.86 ± 2.59 0.480
CHE (U/L) 4012.60 ± 1506.31 3936.47 ± 1735.93 0.800
eGFR (ml/min) 98.03 ± 30.37 100.57 ± 32.53 0.720
INR 2.53 ± 1.31 2.72 ± 0.98 0.098
Lactate 2.10 ± 1.58 2.30 ± 1.26 0.260
MAP 84.11 ± 10.70 85.90 ± 10.11 0.260
HBV-DNA 7.70E + 04 (2.04E + 03,6.75E + 07) 2.39E + 05 (2.63E + 04,1.08E + 08) 0.120
HE    
 Yes/no 16/59 7/23 1.000
Ascite    
 Yes/no 71/4 30/0 0.470
AKI    
 Yes/no 13/62 7/23 0.479
MELD score 24.81 ± 6.68 26.10 ± 5.68 0.355
AARC score 8.68 ± 1.85 9.27 ± 1.82 0.143
ALBI score − 1.04 ± 0.45 − 1.04 ± 0.44 0.830
  1. CHB, chronic hepatitis B; HBC, hepatitis B cirrhosis; ALB, albumin; TBIL, total bilirubin; Na, serum sodium; Cr, creatinine; BUN, blood urea nitrogen; CHE, cholinesterase; eGFR, estimated glomerular filtration rate; INR, international normalized ratio; MAP, mean arterial pressure; HE, hepatic encephalopathy; AKI, acute renal injury; MELD, model for end-stage liver disease; AARC, APASL ACLF research consortium; ALBI, albumin-bilirubin