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Table 1 Patient characteristics and laboratory parameters

From: Hypercortisolism in patients with cholestasis is associated with disease severity

Parameter

Cholestasis group

n = 36

Control group

n = 32

p value

Age

57.3 ± 17.0

62.6 ± 18.2

0.222*

Sex (female)

12 (33%)

12 (38%)

n.s

Bilirubin (mg/dL)

8.3 ± 6.4

0.7 ± 0.3

 < 0.001*

AP (U/L)

450.5 ± 245.0

79.8 ± 24.6

 < 0.001*

GGT (U/L)

549 (318–1187)

35 (19–104)

 < 0.001**

AST (U/L)

112.5 (69–212)

22.5 (17–31)

 < 0.001**

ALT (U/L)

171 (91–313)

23.5 (17–31)

 < 0.001**

Total serum bile acids (µmol/L)

156.9 (22.9–223.4)

1.7 (1.1–3.6)

 < 0.001**

CRP (mg/L)

9.8 (4.2–40.0)

2.5 (1.1–5.4)

0.009**

Aldosterone (ng/mL)

6.8 (3.7–10.5)

4.1 (3.7–11.7)

0.184**

Renin (µg/mL)

19.2 (6.9–43.6)

12.6 (5.1–29.7)

0.508**

DHEA (µg/mL)

0.5 (0.2–1.0)

0.7 (0.3–1.4)

0.143**

Androstenedione (ng/mL)

2.0 ± 1.0

3.0 ± 1.8

0.035*

  1. AP, alkaline phosphatase; GGT, gamma-glutamyltransferase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CRP, C-reactive protein; DHEAS, dehydroepiandrosterone sulfate
  2. *Student’s T test applied; **Mann–Whitney-U test applied