From: Hypercortisolism in patients with cholestasis is associated with disease severity
Parameter | Cholestasis group n = 36 | Control group n = 32 | p value |
---|---|---|---|
Age | 57.3 ± 17.0 | 62.6 ± 18.2 | 0.222* |
Sex (female) | 12 (33%) | 12 (38%) | n.s |
Bilirubin (mg/dL) | 8.3 ± 6.4 | 0.7 ± 0.3 | < 0.001* |
AP (U/L) | 450.5 ± 245.0 | 79.8 ± 24.6 | < 0.001* |
GGT (U/L) | 549 (318–1187) | 35 (19–104) | < 0.001** |
AST (U/L) | 112.5 (69–212) | 22.5 (17–31) | < 0.001** |
ALT (U/L) | 171 (91–313) | 23.5 (17–31) | < 0.001** |
Total serum bile acids (µmol/L) | 156.9 (22.9–223.4) | 1.7 (1.1–3.6) | < 0.001** |
CRP (mg/L) | 9.8 (4.2–40.0) | 2.5 (1.1–5.4) | 0.009** |
Aldosterone (ng/mL) | 6.8 (3.7–10.5) | 4.1 (3.7–11.7) | 0.184** |
Renin (µg/mL) | 19.2 (6.9–43.6) | 12.6 (5.1–29.7) | 0.508** |
DHEA (µg/mL) | 0.5 (0.2–1.0) | 0.7 (0.3–1.4) | 0.143** |
Androstenedione (ng/mL) | 2.0 ± 1.0 | 3.0 ± 1.8 | 0.035* |