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Table 1 Patient characteristics at the time of histological diagnosis of non-alcoholic fatty acid liver disease (NAFLD)

From: PNPLA3 genotype and fibrosis-4 index predict cardiovascular diseases of Japanese patients with histopathologically-confirmed NAFLD

Demographic data

 

Numbers of patients

477

Gender, male/female, n

282/195

Age, year*

53 (20–87)

Body mass index, kg/m2*

26.3 (16.6–42.4)

Waist circumference, cm*

91.3 (68.2–132.1)

Smoking, absence/presence, n

385 /92

Previous or current events

 

Cardiovascular diseases, absence/presence/unknown, n

444/30/3

Malignancies, except for liver cancer, absence/presence/unknown, n

426/47/4

Liver-related events, absence/presence/unknown, n

432/42/3

 Liver cancer, absence/presence/unknown, n

446/30/1

 Ascites, absence/presence/unknown, n

472/2/3

 Hepatic encephalopathy, absence/presence/unknown, n

474/0/3

 Jaundice, absence/presence/unknown, n

471/3/3

 Esophago-gastric varices, absence/presence/unknown, n

463/11/3

Comorbid diseases

 

Type 2 diabetes mellitus, absence/presence, n

321/156

Hypertension, absence/presence, n

256/221

Dyslipidemia, absence/presence, n

125/352

Hyperuricemia, absence/presence, n

420/57

Chronic kidney disease, absence/presence, n

445/32

Histological findings

 

Steatosis, 5–33%/ > 33–66%/ > 66%, n

174/175/126

Lobular inflammation

 

 No foci/< 2 foci/2–4 foci/> 4 foci per 200 × field, n

28/263/167/17

Ballooning, none/few cells/many cells, n

42/298/135

Fibrosis stage, 0/1/2/3/4, n

55/189/77/121/35

NAFLD activity score, ≤ 2/3/4/ ≥ 5, n

38/197/242

Genetic factors

 

PNPLA3 rs738409 (CC/CG/GG/Not determined)

57/137/135/148

TM6SF2 rs58542926 (CC/CT/TT/Not determined)

248/74/7/148

ALDH2 rs671 (GG/GA/AA/Not determined)

158/142/29/148

HSD17B13 rs6834314 (AA/AG/GG/Not determined)

162/132/25/158

Laaboratory dataa

 

Serum aspartate aminotransferase (AST), U/L

44 (3–378)

Serum alanine aminotransferase (ALT), U/L

69 (13–783)

Gamma-glutamyl transpeptidase, U/L

71 (11–1,135)

Platelet count, × 103/mm3

212 (40–471)

Albumin

4.1 (2.8–6.9)

Serum ferritin, μg/L

227 (< 10–2.067)

High sensitive C-reactive protein, mg/dL

0.097 (0.004–2.240)

FIB-4 index

1.36 (0.19–14.8)

  1. Data represent number of patients, except those denoted by a, which represent the median (range) values
  2. Cardiovascular diseases included coronary artery disease, heart valve disease, arrhythmia, heart failure, hypertension, orthostatic hypotension, shock, endocarditis, diseases of the aorta and its branches, disorders of the peripheral vascular system, and stroke
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BMC Gastroenterology

ISSN: 1471-230X

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