Group | N (%) | N events (%) | Incidence rate (95% CI) per 1000 PY | HR* (95% CI) | Adjusted HR** (95% CI) | |||
---|---|---|---|---|---|---|---|---|
Liver disease | Comparators | Liver disease | Comparators | Liver disease | Comparators | |||
Overall | 42 320 (100%) | 182 147 (100%) | 161 (0.38%) | 435 (0.24%) | 7.7 (6.5–8.9) | 4.8 (4.4–5.3) | 1.49 (1.24–1.79) | 1.36 (1.11–1.66) |
Follow-up, months | ||||||||
0 to < 1 | 42 320 (100%) | 182 147 (100%) | – (0.00%) | 1 (0.00%) | – | 0.1 (0.0–0.2) | – | – |
1 to < 2 | 42 218 (99.8%) | 181 946 (99.9%) | 27 (0.06%) | 56 (0.03%) | 7.7 (4.8–10.6) | 3.7 (2.7–4.7) | 1.91 (1.20–3.04) | 1.42 (0.83–2.43) |
2 to < 3 | 42 060 (99.4%) | 181 707 (99.8%) | 69 (0.16%) | 173 (0.10%) | 19.7 (15.1–24.4) | 11.4 (9.7–13.1) | 1.58 (1.19–2.10) | 1.61 (1.17–2.22) |
3 to < 4 | 41 880 (99.0%) | 181 334 (99.6%) | 49 (0.12%) | 122 (0.07%) | 14.1 (10.1–18.0) | 8.1 (6.6–9.5) | 1.60 (1.15–2.25) | 1.56 (1.07–2.26) |
4 to < 5 | 41 744 (98.6%) | 181 046 (99.4%) | 13 (0.03%) | 79 (0.04%) | 3.7 (1.7–5.8) | 5.2 (4.1–6.4) | 0.71 (0.39–1.28) | 0.45 (0.22–0.92) |
5 to < 6 | 41 635 (98.4%) | 180 807 (99.3%) | 3 (0.01%) | 4 (0.00%) | 0.9 (0.0–1.9) | 0.3 (0.0–0.6) | 2.78 (0.60–12.78) | – |
Sex | ||||||||
Females | 21 591 (51.0%) | 93 906 (51.6%) | 60 (0.28%) | 195 (0.21%) | 5.7 (4.2–7.1) | 4.2 (3.6–4.8) | 1.24 (0.92–1.65) | 1.03 (0.74–1.43)Ψ |
Males | 20 729 (49.0%) | 88 241 (48.4%) | 101 (0.49%) | 240 (0.27%) | 9.9 (8.0–11.9) | 5.5 (4.8–6.2) | 1.69 (1.34–2.14) | 1.64 (1.26–2.15) |
Age at index date | ||||||||
< 18 years | 2 769 (6.5%) | 12 877 (7.1%) | 2 (0.07%) | 5 (0.04%) | 1.5 (0.0–3.5) | 0.8 (0.1–1.5) | 1.93 (0.37–9.98) | 2.43 (0.35–16.95)Ψ |
18 to < 40 years | 13 574 (32.1%) | 61 290 (33.6%) | 38 (0.28%) | 90 (0.15%) | 5.7 (3.9–7.5) | 3.0 (2.4–3.6) | 1.86 (1.27–2.73) | 1.80 (1.18–2.77) |
40 to < 60 years | 18 446 (43.6%) | 79 416 (43.6%) | 85 (0.46%) | 206 (0.26%) | 9.4 (7.4–11.4) | 5.3 (4.5–6.0) | 1.72 (1.33–2.23) | 1.64 (1.24–2.18) |
≥ 60 years | 7 531 (17.8%) | 28 564 (15.7%) | 36 (0.48%) | 134 (0.47%) | 9.9 (6.6–13.1) | 9.6 (8.0–11.2) | 0.91 (0.62–1.32) | 0.69 (0.45–1.07) |
Index year | ||||||||
1969–1989 | 2 966 (7.0%) | 11 276 (6.2%) | 8 (0.27%) | 20 (0.18%) | 5.5 (1.7–9.3) | 3.6 (2.0–5.2) | 1.45 (0.63–3.32) | 0.98 (0.36–2.69) |
1990–1999 | 11 722 (27.7%) | 47 935 (26.3%) | 50 (0.43%) | 137 (0.29%) | 8.7 (6.3–11.1) | 5.8 (4.8–6.8) | 1.38 (1.00–1.92) | 1.44 (1.02–2.04) |
2000–2009 | 15 979 (37.8%) | 69 263 (38.0%) | 56 (0.35%) | 165 (0.24%) | 7.1 (5.3–9.0) | 4.8 (4.1–5.6) | 1.35 (0.99–1.84) | 1.07 (0.75–1.53) |
2010–2017 | 11 653 (27.5%) | 53 673 (29.5%) | 47 (0.40%) | 113 (0.21%) | 8.2 (5.9–10.6) | 4.3 (3.5–5.0) | 1.84 (1.31–2.60) | 1.63 (1.08–2.45) |
Age at start of follow-up | ||||||||
< 18 years | 508 (1.2%) | 2 479 (1.4%) | – (0.00%) | – (0.00%) | – | – | – | – |
18 to < 40 years | 4 105 (9.7%) | 19 274 (10.6%) | 7 (0.17%) | 7 (0.04%) | 3.4 (0.9–6.0) | 0.7 (0.2–1.3) | 4.67 (1.63–13.36) | 11.45 (2.17–60.51)Ψ |
40 to < 60 years | 13 567 (32.1%) | 62 844 (34.5%) | 48 (0.35%) | 95 (0.15%) | 7.2 (5.1–9.2) | 3.1 (2.4–3.7) | 2.44 (1.72–3.45) | 2.02 (1.34–3.05) |
≥ 60 years | 24 140 (57.0%) | 97 550 (53.6%) | 106 (0.44%) | 333 (0.34%) | 9.0 (7.3–10.7) | 6.9 (6.2–7.7) | 1.21 (0.97–1.51) | 1.12 (0.88–1.43) |
Country of birth | ||||||||
Nordic | 36 036 (85.2%) | 162 473 (89.2%) | 115 (0.32%) | 304 (0.19%) | 6.5 (5.3–7.7) | 3.8 (3.4–4.2) | 1.46 (1.17–1.82) | 1.36 (1.07–1.72) |
Other | 6 284 (14.8%) | 19 670 (10.8%) | 46 (0.73%) | 131 (0.67%) | 14.9 (10.6–19.2) | 13.5 (11.2–15.8) | 1.87 (1.00–3.49) | 1.73 (0.83–3.60) |
Level of education | ||||||||
≤ 9 years | 9 467 (22.4%) | 33 283 (18.3%) | 50 (0.53%) | 119 (0.36%) | 10.8 (7.8–13.8) | 7.3 (6.0–8.6) | 1.73 (1.05–2.87) | 1.45 (0.83–2.53) |
10–12 years | 20 139 (47.6%) | 83 677 (45.9%) | 76 (0.38%) | 196 (0.23%) | 7.7 (6.0–9.4) | 4.7 (4.1–5.4) | 1.44 (1.05–1.99) | 1.74 (1.20–2.51) |
> 12 years | 12 567 (29.7%) | 64 460 (35.4%) | 34 (0.27%) | 113 (0.18%) | 5.5 (3.6–7.3) | 3.5 (2.9–4.2) | 1.06 (0.63–1.80) | 1.05 (0.58–1.92) |