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Table 3 Multivariate Cox regression models for short-term mortality in ACLF patients

From: Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure

 

HR (95% CI)

p value

Bootstrapping p value

Mortality at 30 days

   

 Model 1: MELD score

   

 MELD ≥ 23.1

3.62 (1.93–6.76)

 < 0.001

0.001

suPAR ≥ 14.7

3.72 (2.15–6.41)

 < 0.001

0.001

 WBC ≥ 6.6

1.96 (1.10–3.51)

0.02

0.016

Model 2: SOFA score

   

 SOFA ≥ 9.5

3.18 (1.67–6.10)

 < 0.001

0.001

 suPAR ≥ 14.7

3.52 (2.02–6.13)

 < 0.001

0.001

 WBC ≥ 6.6

2.03 (1.13–3.67)

0.02

0.017

Model 3 Other Clinical Data

   

 suPAR ≥ 14.7

4.77 (2.78–8.19)

 < 0.001

0.006

 Sepsis

7.48 (2.25–24.85)

0.001

0.009

 Cirrhosis

–

0.25

0.30

 UGIB

–

0.40

0.78

 HRS

–

0.09

0.15

Mortality at 90 days

   

Model 1: MELD score

   

 MELD ≥ 23.1

3.19 (1.88–5.41)

 < 0.001

0.001

 suPAR ≥ 14.7

3.02 (1.90–4.81)

 < 0.001

0.001

 WBC ≥ 6.6

1.97 (1.21–3.21)

0.007

0.008

 Age ≥ 46.5

2.51 (1.54–4.08)

 < 0.001

0.003

Model 2: SOFA score

   

SOFA ≥ 9.5

2.54 (1.51–4.29)

 < 0.001

0.001

suPAR ≥ 14.7

2.89 (1.78–4.69)

 < 0.001

0.001

WBC ≥ 6.6

2.00 (1.22–3.27)

0.006

0.007

Age ≥ 46.5

2.73 (1.68–4.45)

 < 0.001

0.001

Model 3 Other Clinical Data

   

suPAR ≥ 14.7

4.52 (2.87–7.14)

 < 0.001

0.003

Sepsis

7.33 (2.21–24.32)

0.001

0.02

Cirrhosis

–

0.10

0.15

UGIB

–

0.24

0.58

HRS

–

0.12

0.24

  1. UGIB upper gastrointestinal bleeding; HRS hepatorenal syndrome, WBC white blood cell count; MELD Model for End-stage Liver Disease; SOFA sequential organ failure assessment
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BMC Gastroenterology

ISSN: 1471-230X

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