Table 3 Results of univariate and multivariate analysis on potential prognostic factors affecting survival after chemoembolization
Prognostic factors | Number of cases | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | ||
Age (≤ 65/ > 65 years) | 200/137 | 0.91 (0.70‒1.20) | 0.512 | ||
Gender (male/female) | 234/103 | 0.88 (0.66‒1.18) | 0.392 | ||
Alcohol drinking (no/yes) | 283/54 | 0.88 (0.61‒1.25) | 0.470 | ||
Hepatitis B virus carrier (no/yes) | 175/162 | 0.99 (0.76‒1.29) | 0.956 | ||
Hepatitis C virus carrier (no/yes) | 247/90 | 1.01 (0.75‒1.35) | 0.963 | ||
Child–Pugh score (A/B) | 240/97 | 0.56 (0.43‒0.74) | < 0.001 | ||
ALBI score (1, 2, and 3) | 88/249 | 0.49 (0.35‒0.69) | < 0.001 | 0.48 (0.34‒0.68) | < 0.001* |
Total Bilirubin (≤ 1.0/ > 1.0 mg/dl) | 194/143 | 0.59 (0.45‒0.77) | < 0.001 | ||
Albumin (> 3.5/ ≤ 3.5 g/dl) | 159/178 | 0.47 (0.36‒0.62) | < 0.001 | ||
INR (≤ 1.2/ > 1.2) | 138/199 | 0.61 (0.46‒0.80) | < 0.001 | ||
Platelet (> 105/ ≤ 105 mm3) | 170/167 | 0.81 (0.62‒1.05) | 0.113 | ||
Serum AFP level (≤ 200/ > 200 ng/ml) | 257/80 | 0.73 (0.54‒0.99) | 0.041 | 0.63 (0.46‒0.86) | 0.003* |
Ascites (no/yes) | 290/47 | 0.60 (0.42‒0.86) | 0.005 | ||
BCLC-staging (0‒A/B) | 186/151 | 0.64 (0.49‒0.83) | < 0.001 | ||
Size of largest tumor (≤ 3/ > 3 cm) | 151/186 | 0.71 (0.54‒0.93) | 0.012 | ||
Single tumor (yes/no) | 180/157 | 0.71 (0.54‒0.92) | 0.011 | ||
Unilobar involvement (yes/no) | 283/54 | 0.82 (0.58‒1.16) | 0.262 | ||
Up-to-7 criteria (within/beyond) | 267/70 | 0.88 (0.64‒1.22) | 0.447 | ||
CR at 1 month after cTACE (yes/no) | 162/175 | 0.34 (0.26‒0.46) | < 0.001 | 0.55 (0.40‒0.75) | < 0.001* |
CBCT with AFD software assisted cTACE (yes/no) | 196/141 | 0.34 (0.26‒0.44) | < 0.001 | 0.38 (0.28‒0.51) | < 0.001* |