Table 2 Etiology of chronic diarrhea in this cohort
Diseases | Number of patients (%) (N = 550) |
|---|---|
Infections | |
Parasites/Protozoa | 27 (4.91%) |
Tuberculosis | 19 (3.45%) |
Cytomegalovirus | 19 (3.45%) |
Clostridium difficile infection* | 8 (1.45%) |
Bacteria other than C. difficile | 5 (0.91%) |
Neoplasm | |
Colonic adenocarcinoma | 40 (7.27%) |
Gastrointestinal lymphoma | 9 (1.64%) |
Polyposis syndrome (Peutz-Jeghers syndrome, Cronkhite-Canada syndrome) | 2 (0.36%) |
Inflammatory bowel disease | |
Crohn’s disease | 20 (3.64%) |
Ulcerative colitis | 31 (5.64%) |
Microscopic colitis | 5 (0.91%) |
Systemic autoimmune diseases | |
Systemic lupus erythematosus | 5 (0.91%) |
Behcet’s disease | 3 (0.55%) |
Drugs | |
Nonsteroidal anti-inflammatory agents | 14 (2.55%) |
Chemotherapy/targeted therapy | 9 (1.64%) |
Others e.g. colchicine, metformin | 7 (1.27%) |
Eosinophilic gastroenteritis | 24 (4.36%) |
Radiation enterocolitis | 7 (1.27%) |
Ischemic enterocolitis | 3 (0.55%) |
Graft-versus-host diseases | 4 (0.73%) |
Gastrointestinal amyloidosis | 3 (0.55%) |
Small intestinal bacterial overgrowth | 21 (3.82%) |
Pancreatic diseases | |
Chronic pancreatitis | 6 (1.09%) |
Pancreatic cancer | 4 (0.73%) |
Status post pancreatic resection | 1 (0.18%) |
Endocrinologic diseases | |
Diabetic diarrhea | 16 (2.91%) |
Hyperthyroidism | 3 (0.55%) |
Adrenal insufficiency | 2 (0.36%) |
Bile salt diarrhea | 4 (0.73%) |
Lactose intolerance | 2 (0.36%) |
Irritable bowel syndrome | 215 (39.09%) |
Idiopathic ulcers of intestine | 4 (0.73%) |
Idiopathic diarrhea | 2 (0.36%) |
Others (1 per each etiology): tropical sprue, intestinal lymphangiectasia, systemic mastocytosis, mesenteric neuroendocrine tumor, chronic diverticulitis, portal hypertensive colopathy) | 6 (1.09%) |