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Table 2 Prediction of increased stage of HBV-ACLF, ascites, and hepatic encephalopathy with decreased androgen levels

From: Lower testosterone levels predict increasing severity and worse outcomes of hepatitis B virus-related acute-on-chronic liver failure in males

 

HBV-ACLF

Ascites

Hepatic encephalopathy

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value

1–Ln (TT [ng/dL])

3.507 (2.285–5.383)

 < 0.001

2.962 (1.957–4.482)

 < 0.001

3.052 (1.690–5.513)

 < 0.001

1–Ln (SHBG [nmol/L])

8.757 (4.046–18.951)

 < 0.001

4.293 (2.118–8.701)

 < 0.001

17.010 (5.361–53.975)

 < 0.001

1–Ln (FTI [%])

2.376 (1.469–3.841)

 < 0.001

2.374 (1.472–3.829)

 < 0.001

1.453 (0.783–2.696)

0.236

SQRT (DHEAS [μg/dL])

1.042 (0.981–1.106)

0.186

0.971 (0.915–1.031)

0.341

1.172 (1.079–1.273)

 < 0.001

SQRT (cortisol [μg/dL])

1.077 (0.832–1.393)

0.573

1.028 (0.804–1.313)

0.827

1.248 (0.924–1.686)

0.148

SQRT (AND [ng/mL])

2.089 (1.139–3.830)

0.017

1.390 (0.773–2.501)

0.272

3.296 (1.473–7.375)

0.004

  1. Model was adjusted for age and body mass index
  2. Subjects were categorized according to stage of hepatitis B virus-related acute-on-chronic liver failure (early stage, middle stage, or end stage), ascites (none, mild ascites, or severe ascites), and hepatic encephalopathy (none, grade I/II, or grade III/IV)
  3. HBV-ACLF Hepatitis B virus-related acute-on-chronic liver failure, TT total testosterone, SHBG sex-hormone-binding globulin, FTI free testosterone index, SQRT Square Root, DHEAS dehydroepiandrosterone sulfate, AND androstenedione
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BMC Gastroenterology

ISSN: 1471-230X

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