Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

Wu, Shi-yi; Liao, Pan; Yan, Lu-yu; Zhao, Qian-yi; Xie, Zhao-yu; Dong, Jie; Sun, Hong-tao

doi:10.1186/s12876-021-01984-2

BMC Gastroenterology

Table 2 Association of MKI67 with immune cell gene markers in LIHC detected through TIMER

From: Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

Immune cell	Gene markers	None		Purity
Immune cell	Gene markers	Cor	P value	Cor	P value
CD8+ T cell	CD8A	0.218	***	0.211	***
	CD8B	0.180	**	0.182	**
T cell	CD6	0.214	***	0.215	***
	CD3D	0.279	***	0.278	***
	CD3E	0.217	***	0.214	***
	SH2D1A	0.195	**	0.194	**
	TRAT1	0.183	**	0.196	**
	CD3G	0.279	***	0.274	***
	CD2	0.224	***	0.227	***
B cell	CD19	0.247	***	0.242	***
	FCRL2	0.202	***	0.214	***
	KIAA0125	0.146	*	0.146	*
	TNFRSF17	0.133	0.01	0.142	*
	SPIB	0.376	***	0.357	***
	PNOC	0.197	**	0.211	***
	CD79A	0.176	**	0.172	*
Monocyte	CD86	0.316	***	0.314	***
	CD115(CSF1R)	0.184	**	0.190	**
TAM	CD68	0.272	***	0.263	***
	IL10	0.249	***	0.240	***
M1 Macrophage	IRF5	0.412	***	0.411	***
	COX2(PTGS2)	0.138	*	0.151	*
M2 Macrophage	CD163	0.106	0.041	0.109	0.042
	MS4A4A	0.119	0.022	0.128	0.017
Neutrophils	FPR1	0.239	***	0.244	***
	SIGLEC5	0.296	***	0.304	***
	CSF3R	0.307	***	0.302	***
	FCGR3B	0.158	*	0.153	*
	CEACAM3	0.120	0.021	0.136	0.017
	CD116(ITGAM)	0.296	***	0.312	***
Natural killer cell	XCL2	0.210	***	0.226	***
	KIR2DL1	− 0.003	0.955	− 0.023	0.668
	KIR2DL3	0.177	**	0.189	**
	KIR2DL4	0.177	**	0.167	*
Dendritic cell	CCL13	0.181	**	0.162	*
	CD209	0.171	**	0.180	**
	HSD11B1	− 0.352	***	− 0.344	***
	HLA-DPB1	0.185	**	0.185	**
	HLA-DQB1	0.148	*	0.148	*
	HLA-DRA	0.196	**	0.199	**
	HLA-DPA1	0.176	**	0.186	**
	BCDA-1(CD1C)	0.136	*	0.141	*
	BDCA-4(NRP1)	0.291	***	0.296	***
	CD11c(ITGAX)	0.363	***	0.354	***
Mast cell	TPSB2	− 0.028	0.595	− 0.044	0.413
	HDC	− 0.166	*	− 0.175	*
Th1	IFN-γ(IFNG)	0.269	***	0.282	***
	TNF-α(TNF)	0.288	***	0.299	***
	STAT4	0.259	***	0.263	***
	STAT1	0.379	***	0.379	***
Th2	GATA3	0.250	***	0.258	***
	STAT6	0.162	*	0.157	*
	STAT5A	0.329	***	0.329	***
Tfh	BCL6	0.172	**	0.179	**
	IL21	0.172	**	0.178	**
Th17	STAT3	0.200	**	0.198	**
	IL17A	0.100	0.054	0.099	0.065
Effector T cell	CX3CR1	0.199	**	0.209	***
	FGFBP2	− 0.140	*	− 0.120	0.026
	FCGR3A	0.305	***	0.309	***
Effector memory T cell	PD-1 (PDCD1)	0.344	***	0.332	***
	DUSP4	0.324	***	0.330	***
Central memory T cell	CCR7	0.131	0.011	0.136	0.011
	SELL	0.175	**	0.188	**
	IL7R	0.176	**	0.185	**
Resident memory T cell	CD69	0.176	**	0.174	*
	ITGAE	0.306	***	0.297	***
	CXCR6	0.201	***	0.203	**
	MYADM	0.391	***	0.375	***
Exhausted T cell	TIM-3 (HAVCR2)	0.344	***	0.345	***
	TIGIT	0.325	***	0.333	***
	LAG3	0.306	***	0.295	***
	CXCL13	0.273	***	0.295	***
	LAYN	0.227	***	0.243	***
Resting Treg T cell	FOXP3	0.194	**	0.223	***
	IL2RA	0.308	***	0.309	***
Effector Treg T cell	CTLA4	0.354	***	0.353	***
	CCR8	0.444	***	0.456	***
	TNFRSF9	0.371	***	0.386	***

TAM, tumor-associated macrophage; LIHC, Liver hepatocellular carcinoma; Treg, regulatory T cells; Tfh, Follicular helper T cells; Th, T helper cells; Purity, tumor purity-adjusted correlation. None, unadjusted correlation; Cor, ρ-value upon Spearman correlation. Significance levels: * P < 0.05; ** P < 0.01; *** P < 0.001

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