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Table 2 Association of MKI67 with immune cell gene markers in LIHC detected through TIMER

From: Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

Immune cell Gene markers None Purity
Cor P value Cor P value
CD8+ T cell CD8A 0.218 *** 0.211 ***
  CD8B 0.180 ** 0.182 **
T cell CD6 0.214 *** 0.215 ***
  CD3D 0.279 *** 0.278 ***
  CD3E 0.217 *** 0.214 ***
  SH2D1A 0.195 ** 0.194 **
  TRAT1 0.183 ** 0.196 **
  CD3G 0.279 *** 0.274 ***
  CD2 0.224 *** 0.227 ***
B cell CD19 0.247 *** 0.242 ***
  FCRL2 0.202 *** 0.214 ***
  KIAA0125 0.146 * 0.146 *
  TNFRSF17 0.133 0.01 0.142 *
  SPIB 0.376 *** 0.357 ***
  PNOC 0.197 ** 0.211 ***
  CD79A 0.176 ** 0.172 *
Monocyte CD86 0.316 *** 0.314 ***
  CD115(CSF1R) 0.184 ** 0.190 **
TAM CD68 0.272 *** 0.263 ***
  IL10 0.249 *** 0.240 ***
M1 Macrophage IRF5 0.412 *** 0.411 ***
  COX2(PTGS2) 0.138 * 0.151 *
M2 Macrophage CD163 0.106 0.041 0.109 0.042
  MS4A4A 0.119 0.022 0.128 0.017
Neutrophils FPR1 0.239 *** 0.244 ***
  SIGLEC5 0.296 *** 0.304 ***
  CSF3R 0.307 *** 0.302 ***
  FCGR3B 0.158 * 0.153 *
  CEACAM3 0.120 0.021 0.136 0.017
  CD116(ITGAM) 0.296 *** 0.312 ***
Natural killer cell XCL2 0.210 *** 0.226 ***
  KIR2DL1 − 0.003 0.955 − 0.023 0.668
  KIR2DL3 0.177 ** 0.189 **
  KIR2DL4 0.177 ** 0.167 *
Dendritic cell CCL13 0.181 ** 0.162 *
  CD209 0.171 ** 0.180 **
  HSD11B1 − 0.352 *** − 0.344 ***
  HLA-DPB1 0.185 ** 0.185 **
  HLA-DQB1 0.148 * 0.148 *
  HLA-DRA 0.196 ** 0.199 **
  HLA-DPA1 0.176 ** 0.186 **
  BCDA-1(CD1C) 0.136 * 0.141 *
  BDCA-4(NRP1) 0.291 *** 0.296 ***
  CD11c(ITGAX) 0.363 *** 0.354 ***
Mast cell TPSB2 − 0.028 0.595 − 0.044 0.413
  HDC − 0.166 * − 0.175 *
Th1 IFN-γ(IFNG) 0.269 *** 0.282 ***
  TNF-α(TNF) 0.288 *** 0.299 ***
  STAT4 0.259 *** 0.263 ***
  STAT1 0.379 *** 0.379 ***
Th2 GATA3 0.250 *** 0.258 ***
  STAT6 0.162 * 0.157 *
  STAT5A 0.329 *** 0.329 ***
Tfh BCL6 0.172 ** 0.179 **
  IL21 0.172 ** 0.178 **
Th17 STAT3 0.200 ** 0.198 **
  IL17A 0.100 0.054 0.099 0.065
Effector T cell CX3CR1 0.199 ** 0.209 ***
  FGFBP2 − 0.140 * − 0.120 0.026
  FCGR3A 0.305 *** 0.309 ***
Effector memory T cell PD-1 (PDCD1) 0.344 *** 0.332 ***
  DUSP4 0.324 *** 0.330 ***
Central memory T cell CCR7 0.131 0.011 0.136 0.011
  SELL 0.175 ** 0.188 **
  IL7R 0.176 ** 0.185 **
Resident memory T cell CD69 0.176 ** 0.174 *
  ITGAE 0.306 *** 0.297 ***
  CXCR6 0.201 *** 0.203 **
  MYADM 0.391 *** 0.375 ***
Exhausted T cell TIM-3 (HAVCR2) 0.344 *** 0.345 ***
  TIGIT 0.325 *** 0.333 ***
  LAG3 0.306 *** 0.295 ***
  CXCL13 0.273 *** 0.295 ***
  LAYN 0.227 *** 0.243 ***
Resting Treg T cell FOXP3 0.194 ** 0.223 ***
  IL2RA 0.308 *** 0.309 ***
Effector Treg T cell CTLA4 0.354 *** 0.353 ***
  CCR8 0.444 *** 0.456 ***
  TNFRSF9 0.371 *** 0.386 ***
  1. TAM, tumor-associated macrophage; LIHC, Liver hepatocellular carcinoma; Treg, regulatory T cells; Tfh, Follicular helper T cells; Th, T helper cells; Purity, tumor purity-adjusted correlation. None, unadjusted correlation; Cor, ρ-value upon Spearman correlation. Significance levels: * P < 0.05; ** P < 0.01; *** P < 0.001