Table 3 Available clinical trials of probiotics in the treatment of H. pylori infection in children
From: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections
First author | Year | Type of study | Eradication therapy | Probiotic regimen | Duration | Cure rate | Statistical significance | Ref | |
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Â | Case | Control | Â | Â |
Gotteland et al | 2005 | Open randomized | NA | Saccharomyces boulardii, L. acidophilus | 8 weeks | 12%, 6.5% | 0% | p < 0.000 | [152] |
Sykora et al | 2005 | Double blind randomized | Omeprazole, amoxicillin, clarithromycin for 7 days | L. casei DN-114 001 | 2 weeks | 84.6% | 57.4% | p = 0.0019 | [156] |
Goldman et al | 2006 | Double blind randomized | Omeprazole, amoxicillin, clarithromycin for 7 days | B. animalis + L. casei | 3 months | 45.4% | 37.5% | p < 0.01 | [157] |
Lionetti et al | 2006 | Double blind randomized | Omeprazole, amoxicillin, clarithromycin, tinidazole (sequential therapy) | L. reuteri ATCC 55,730 | 20 days | 85% | 80% | p < 0.009 | [158] |
Gotteland et al | 2008 | Double blind randomized | NA | L. jonsonii La1 plus cranberry, L. jonshonii La1, cranberry plus heat-killed L. jonsonii La1 | 3 weeks | 22.9%, 14.9%, 16.9% | 1.5% | p = 0.542 | [159] |
Hurduc et al | 2009 | Open randomized | Omeprazole, amoxicillin, clarithromycin for 7 days | Saccharomyces boulardi | 4 weeks | 93.7% | 80.9% | p < 0.002 | [82] |
Szajewska et al | 2009 | Double blind randomized | Omeprazole, amoxicillin, clarithromycin for 7Â days | L. rhamnosus GG | 1Â weeks | 67.6% | 68.7% | Not significant | [160] |
Boonyaricaikij et al | 2009 | Single blind | NA | L. gasseri OLL2716 | 1 years | 29.3% | 6.6% | p = 0.03 | [161] |
Tolone et al | 2012 | NA | Omeprazole, amoxicillin, clarithromycin for 7 days | Probinul-Cadigroup | NA | 88.2% | 76.4% | p < 0.05 | [162] |
Zhao et al | 2014 | prospective randomized controlled study | Omeprazole, amoxicillin, clarithromycin for 7 days | Saccharomyces boulardii | 7 days | 85% | 75.8% | p < 0.05 | [163] |
Wang et al | 2014 | NA | Omeprazole, amoxicillin, clarithromycin for 7 days | L. acidophilus, B. bifidum | 2 weeks | 83.7% | 64.4% | p < 0.05 | [164] |
Akcam et al | 2015 | Open randomized | triple therapy (lansoprazole, amoxicillin, clarithromycin for 14 days) | L. casei, L. acidophilus, B. lactis | 2 weeks | 66.6% | 68.9% | p = 0.78 | [165] |
Zhu etal | 2017 | Double blind randomized | Sequential, Triple therapy | Sequential-Lactobacillus, triple-Lactobacillus therapy | NA |  | Sequential-Lactobacillus and triple-Lactobacillus better than any of them alone (P < 0.05) | p < 0.01 | [166] |