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Table 3 Available clinical trials of probiotics in the treatment of H. pylori infection in children

From: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections

First author Year Type of study Eradication therapy Probiotic regimen Duration Cure rate Statistical significance Ref
       Case Control   
Gotteland et al 2005 Open randomized NA Saccharomyces boulardii, L. acidophilus 8 weeks 12%, 6.5% 0% p < 0.000 [152]
Sykora et al 2005 Double blind randomized Omeprazole, amoxicillin, clarithromycin for 7 days L. casei DN-114 001 2 weeks 84.6% 57.4% p = 0.0019 [156]
Goldman et al 2006 Double blind randomized Omeprazole, amoxicillin, clarithromycin for 7 days B. animalis + L. casei 3 months 45.4% 37.5% p < 0.01 [157]
Lionetti et al 2006 Double blind randomized Omeprazole, amoxicillin, clarithromycin, tinidazole
(sequential therapy)
L. reuteri ATCC 55,730 20 days 85% 80% p < 0.009 [158]
Gotteland et al 2008 Double blind randomized NA L. jonsonii La1 plus cranberry, L. jonshonii La1, cranberry plus heat-killed L. jonsonii La1 3 weeks 22.9%, 14.9%, 16.9% 1.5% p = 0.542 [159]
Hurduc et al 2009 Open randomized Omeprazole, amoxicillin, clarithromycin for 7 days Saccharomyces boulardi 4 weeks 93.7% 80.9% p < 0.002 [82]
Szajewska et al 2009 Double blind randomized Omeprazole, amoxicillin, clarithromycin for 7 days L. rhamnosus GG 1 weeks 67.6% 68.7% Not significant [160]
Boonyaricaikij et al 2009 Single blind NA L. gasseri OLL2716 1 years 29.3% 6.6% p = 0.03 [161]
Tolone et al 2012 NA Omeprazole, amoxicillin, clarithromycin for 7 days Probinul-Cadigroup NA 88.2% 76.4% p < 0.05 [162]
Zhao et al 2014 prospective randomized controlled study Omeprazole, amoxicillin, clarithromycin for 7 days Saccharomyces boulardii 7 days 85% 75.8% p < 0.05 [163]
Wang et al 2014 NA Omeprazole, amoxicillin, clarithromycin for 7 days L. acidophilus, B. bifidum 2 weeks 83.7% 64.4% p < 0.05 [164]
Akcam et al 2015 Open randomized triple therapy (lansoprazole, amoxicillin, clarithromycin for 14 days) L. casei, L. acidophilus, B. lactis 2 weeks 66.6% 68.9% p = 0.78 [165]
Zhu etal 2017 Double blind randomized Sequential, Triple therapy Sequential-Lactobacillus, triple-Lactobacillus therapy NA   Sequential-Lactobacillus and triple-Lactobacillus better than any of them alone (P < 0.05) p < 0.01 [166]