Table.3 Metadata association with microbiota composition variation (Bray–Curtis distance, Genus level) by permutational multivariate analysis of variance

Birthmonth

1

0.496807

0.017434

0.963

0.30401

0.010741

0.988

0.893998

0.064344

0.587

Bristol stool

1

1.615966

0.054564

0.09

1.126012

0.03866

0.338

0.591071

0.04349

0.923

Complication

1

0.978535

0.070003

0.404

1.660764

0.11328

0.132

0.835214

0.094532

0.66

Drinking

1

0.904672

0.031298

0.532

0.629747

0.021996

0.741

0.810813

0.058709

0.709

Extraintestinal

1

1.317045

0.091991

0.133

2.485206

0.160489

0.02

0.928086

0.103951

0.494

Fermentedfood

1

0.77691

0.026998

0.666

1.408026

0.047879

0.159

1.137492

0.080459

0.284

Surgery history

1

0.850101

0.029466

0.567

1.764313

0.059276

0.079

1.232748

0.086613

0.191

Age

1

1.33408

0.045479

0.169

1.187432

0.040683

0.266

0.671462

0.049114

0.876

Birthyear

1

1.341552

0.045722

0.17

1.239168

0.04238

0.226

0.662354

0.04848

0.899

BMI

1

1.382341

0.047047

0.17

0.595062

0.02081

0.798

1.964587

0.131282

0.015

Hostcategory

1

2.348238

0.077376

0.013

1.072956

0.036906

0.31

1.07396

0.076308

0.336

Height

1

1.610117

0.054377

0.085

0.387902

0.013664

0.954

0.483476

0.035857

0.981

Sex

1

0.943593

0.032601

0.467

0.733253

0.025519

0.651

0.707142

0.051589

0.852

Weight

1

1.24015

0.042413

0.237

0.591836

0.020699

0.796

1.821861

0.122917

0.025

Hypertension

1

0.428682

0.015079

0.986

0.724504

0.025222

0.662

0.715157

0.052144

0.839

LesionE1, E23

1

0.833943

0.060282

0.646

0.556671

0.041062

0.865

0.772521

0.088061

0.731

LesionE1, E2, E3

2

1.534195

0.203631

0.053

0.702836

0.104857

0.775

1.097036

0.23864

0.359

Medication

1

0.662934

0.023129

0.789

0.6435

0.022466

0.727

0.729636

0.053143

0.818

Ordernumber

8

1.273526

0.326669

0.099

1.151589

0.304928

0.215

1.450733

0.446279

0.02

Pastdisease

9

0.751518

0.252718

0.882

0.887925

0.285493

0.683

0.818017

0.44995

0.899

Period

1

0.954267

0.068385

0.507

1.564211

0.107401

0.122

0.927049

0.103847

0.529

Probiotics

1

0.632417

0.022087

0.839

0.587319

0.020545

0.815

1.1144

0.078955

0.289

Probiotics

1

0.763851

0.026556

0.692

0.634697

0.022165

0.729

1.329072

0.092754

0.139

Samplingdate

8

1.273526

0.326669

0.11

1.151589

0.304928

0.228

1.450733

0.446279

0.032

Smoking

1

0.895662

0.030996

0.489

2.138451

0.070954

0.041

0.859489

0.062014

0.663

Stoolcolor

3

1.27103

0.1279

0.178

0.880472

0.092224

0.592

1.086841

0.22864

0.331

Stooltype

5

1.000135

0.172433

0.46

0.722303

0.130797

0.91

1.107801

0.380976

0.275

Sugarydrink

1

1.472612

0.049965

0.117

0.863336

0.029911

0.506

1.126826

0.079765

0.286

Sugarysnack

1

0.816938

0.028349

0.628

1.283086

0.043817

0.248

0.799636

0.057946

0.727

Surgery

5

1.509554

0.239249

0.053

1.723835

0.264236

0.004

1.419619

0.279107

0.046

Active UC

1

2.21661

0.073357

0.024

1.015076

0.034984

0.346

1.061837

0.075512

0.358

UC activity

1

1.965438

0.131332

0.046

0.693475

0.050643

0.692

0.710533

0.081572

0.811