Table 1 Distribution of candidate predictors and outcomes in study cohort (N = 11,724)

Major Colonoscopy Indication: Signs/symptoms

39.6%

Major Colonoscopy Indication: First-degree relative with CRC

24.9%

Major Colonoscopy Indication: Surveillance (history of polyps)

14.3%

Major Colonoscopy Indication: Asymptomatic screening*

28.2%

Symptom Indication: Rectal bleeding

19.7%

Symptom Indication: Anemia

7.4%

Symptom Indication: Unintentional weight loss

1.6%

Symptom Indication: Other gastrointestinal symptoms

(abdominal or rectal pain, new diarrhea or constipation, rectal urgency, fecal incontinence)

20.3%

Age in years (median (IQR))

61 (55–68)

Male sex

46%

Charlson-Deyo co-morbidity score

 0–1

93.2%

 2 + 

6.8%

History of diabetes mellitus

17.6%

Prior gastrointestinal malignancy (excluding CRC)

0.5%

Any prior malignancy (excluding CRC)

11.1%

Lower endoscopy within past 10 years

42.3%

# Years since most recent lower endoscopy

 < 2

4.9%

 2–4

9.6%

 4–6

18.0%

 6–8

6.7%

 8–10

3.1%

 > 10 (or none)

57.7%

Complete colonoscopy (to cecum) within past 10 years

37.9%

Polypectomy or polyp fulguration within past 10 years

15.6%

Highest neoplasia grade at colonoscopy

Invasive cancer

1.5%

 High-risk adenoma**

11.5%

 Low-risk adenoma or normal

87%