Table 1 Clinical characteristics of PCD patients with paediatric-onset and adult-onset perianal disease
Factors | Patients with POP (N = 84) | Patients with AOP (N = 209) | P value |
|---|---|---|---|
Male, n (%) | 68 (81.0) | 154 (73.7) | 0.228 |
Mean age at CD diagnosis (years ± SD) | 18.0 ± 4.3 | 32.0 ± 10.9 | < 0.01 |
PCD diagnostic delay (months) | 12 (2–48) | 24 (2.5–60) | 0.033 |
Disease location, n (%) | 0.198 | ||
L1, terminal ileum | 19 (22.6) | 55 (26.3) | |
L2, colon | 17 (20.2) | 62 (29.7) | |
L3, ileocolon | 45 (53.6) | 87 (41.6) | |
L4, upper gastrointestinal tract | 3 (3.6) | 5 (2.4) | |
Disease behaviour, n (%) | 0.015 | ||
B1, non-stricturing, non-penetrating | 56 (66.7) | 100 (47.8) | 0.005a |
B2, structuring | 23 (27.4) | 88 (42.1) | 0.024a |
B3, penetrating | 5 (6.0) | 21 (10.0) | 0.364a |
Mean PD onset age (years ± SD) | 15.1 ± 2.9 | 30.2 ± 10.5 | < 0.01 |
Perianal fistula, n (%) | 53 (63.1) | 110 (52.6) | 0.119 |
Complex perianal fistula, n/N (%) | 38/53 (71.7) | 55/110 (50.0) | 0.011 |
Perianal abscess, n (%) | 41 (48.8) | 100 (47.8) | 0.898 |
Hemorrhoids, n (%) | 16 (19.0) | 35 (16.7) | 0.639 |
Anal ulcer, n (%) | 3 (3.6) | 12 (5.7) | 0.430 |
Anal fissures, n (%) | 5 (6.0) | 8 (3.8) | 0.424 |
Rectovaginal fistula, n (%) | 1 (1.2) | 9 (4.3) | 0.153 |
Rectal inflammation, n (%) | 6 (7.1) | 24 (11.5) | 0.268 |
Current smokers, n (%) | 4 (4.8) | 27 (12.9) | 0.040 |
Family history of IBD, n (%) | 4 (4.8)) | 22 (10.5) | 0.117 |
Medications, n (%) | |||
IFX | 28 (33.3) | 46 (22.0) | 0.044 |
Immunomodulators | 5 (6.0) | 13 (6.2) | 0.925 |
Antibiotics | 51 (60.7) | 128 (61.2) | 0.933 |
Corticosteroids | 3 (3.6) | 7 (3.3) | 1.000 |
Time from PCD diagnosis to first use of IFX, months (IQR) | 1.0 (0.1–1.9) | 1.8 (5.3–38.6) | < 0.01 |
Numbers of IFX uses (mean ± SD) | 7.7 ± 0.75 | 7.1 ± 0.6 | 0.472 |
History of PSIs, n (%) | 66 (78.6) | 150 (71.8) | 0.245 |
Frequency of PSIs, n (%) | 0.284 | ||
1 time | 46 (54.8) | 118 (56.5) | |
2 times | 15 (17.9) | 22 (10.5) | |
3 times | 5 (6.0) | 10 (4.8) | |
Types of perianal surgery, n (%) | |||
Incision and drainage | 33 (39.3) | 68 (32.5) | 0.272 |
Seton insertion | 42 (50.0) | 83 (39.7) | 0.107 |
Fistulectomy | 19 (22.6) | 52 (24.9) | 0.764 |
Proctectomy | 0 (0) | 2 (1.0) | 1.000 |
De-functioning | 1 (1.2) | 2 (1.0) | 1.000 |
Procedure for prolapsing haemorrhoids | 7 (8.3) | 14 (6.7) | 0.624 |
CD-related intestinal resection, n (%) | 4 (4.8) | 44 (21.1) | 0.001 |
Indication for surgery, n (%) | 0.815 | ||
Inflammation | 0 (0) | 3 (6.8) | |
Obstruction | 2 (50.0) | 19 (43.2) | |
Perforation | 1 (25.0) | 18 (40.9) | |
Obstruction combined with perforation | 1 (25.0) | 4 (9.1) | |
Extent of resected intestine, n (%) | 0.232 | ||
Partial ileal resection | 2 (50.0) | 20 (45.5) | |
Partial colon resection | 1 (25.0) | 2 (4.5) | |
Ileocolonic resection | 1 (25.0) | 22 (50.0) |