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Table 3 Univariate and multivariate analyses of clinicopathological factors affecting OS after resection of BTC

From: A combined prediction model for biliary tract cancer using the prognostic nutritional index and pathological findings: a single-center retrospective study

Factor Univariate analysis Multivariate analysis
n P-value HR (95% CI) P-value
Age (years)   0.943
  ≥ 75 60    
  < 75 56    
Sex   0.090
 Male 73    
 Female 43    
BMI (kg/m2)   0.460
  ≥ 20 80    
  < 20 36    
CEA level (ng/mL)   0.847
  ≥ 9 17    
  < 9 99    
CA19-9 level (U/mL)   0.013* 1.12 (0.57–2.23) 0.733
  ≥ 20 56    
  < 20 60    
Preoperative cholangitis   0.049* 1.14 (0.62–2.08) 0.653
 Present 43    
 Absent 73    
Comorbidities   0.095
 Present 82    
 Absent 34    
Primary disease   0.090
 ICC 30    
 GBC 29    
 Distal cholangiocarcinoma 27    
 Ampullary carcinoma 17    
 Perihilar cholangiocarcinoma 13    
Surgical procedure   0.540
Cholecystectomy 11    
 Bile duct resection w/o liver resection 1    
 Minor hepatectomy 25    
 Major hepatectomy 35    
 Pancreaticoduodenectomy 42    
 Hepatopancreaticoduodenectomy 2    
Resection    < 0.001*** 1.26 (0.59–2.59) 0.536
 R0 98    
 R1–2 18    
Operation time (minutes)   0.032 * 1.03 (0.49–2.28) 0.948
  ≥ 360 82    
  < 360 34    
Blood loss (mL)   0.550
  ≥ 200 81    
  < 200 35    
Transfusion   0.612
 No 100    
 Yes 16    
T stage    < 0.001*** 1.92 (0.97–4.08) 0.075
  < 3 57    
  ≥ 3 59    
N stage    < 0.001*** 1.99 (1.03–3.90) 0.040*
 0 69    
 1 47    
Tumor differentiation   0.003** 2.45 (1.29–4.83) 0.006**
 Well 48    
 Other 68    
PNI   0.003** 2.12 (1.09–4.04) 0.027**
  < 42 28    
  ≥ 42 88    
GPS   0.065
 0 44    
 1–2 72    
CAR   0.064
  < 1 65    
  ≥ 1 51    
NLR   0.352
  < 2.55 85    
  ≥ 2.55 31    
PLR   0.014* 1.39 (0.69–2.92) 0.357
  < 119 68    
  ≥ 119 48    
Postoperative complications (Clavien–Dindo grade ≥ IIIa)   0.594
 Absent 73    
 Present 43    
Postoperative adjuvant chemotherapy   0.518
 No 36    
 Yes 80    
  1. BMI body mass index, BTC biliary tract cancer, CA19-9 carbohydrate antigen 19-9, CAR CRP to albumin ratio, CEA carcinoembryonic antigen, CI confidence interval, CRP C-reactive protein, GBC gallbladder carcinoma, GPS Glasgow Prognostic Score, HR hazard ratio, ICC intrahepatic cholangiocarcinoma, NLR neutrophil to lymphocyte ratio, OS overall survival, PLR platelet to lymphocyte ratio, PNI prognostic nutritional index, w/o without
  2. *P < 0.05; **P < 0.01; ***P < 0.001