Factor | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
n | P-value | HR (95% CI) | P-value | |
Age (years) |  | 0.943 | – | – |
  ≥ 75 | 60 |  |  |  |
  < 75 | 56 |  |  |  |
Sex |  | 0.090 | – | – |
 Male | 73 |  |  |  |
 Female | 43 |  |  |  |
BMI (kg/m2) |  | 0.460 | – | – |
  ≥ 20 | 80 |  |  |  |
  < 20 | 36 |  |  |  |
CEA level (ng/mL) |  | 0.847 | – | – |
  ≥ 9 | 17 |  |  |  |
  < 9 | 99 |  |  |  |
CA19-9 level (U/mL) |  | 0.013* | 1.12 (0.57–2.23) | 0.733 |
  ≥ 20 | 56 |  |  |  |
  < 20 | 60 |  |  |  |
Preoperative cholangitis |  | 0.049* | 1.14 (0.62–2.08) | 0.653 |
 Present | 43 |  |  |  |
 Absent | 73 |  |  |  |
Comorbidities |  | 0.095 | – | – |
 Present | 82 |  |  |  |
 Absent | 34 |  |  |  |
Primary disease |  | 0.090 | – | – |
 ICC | 30 |  |  |  |
 GBC | 29 |  |  |  |
 Distal cholangiocarcinoma | 27 |  |  |  |
 Ampullary carcinoma | 17 |  |  |  |
 Perihilar cholangiocarcinoma | 13 |  |  |  |
Surgical procedure |  | 0.540 | – | – |
Cholecystectomy | 11 | Â | Â | Â |
 Bile duct resection w/o liver resection | 1 |  |  |  |
 Minor hepatectomy | 25 |  |  |  |
 Major hepatectomy | 35 |  |  |  |
 Pancreaticoduodenectomy | 42 |  |  |  |
 Hepatopancreaticoduodenectomy | 2 |  |  |  |
Resection |  |  < 0.001*** | 1.26 (0.59–2.59) | 0.536 |
 R0 | 98 |  |  |  |
 R1–2 | 18 |  |  |  |
Operation time (minutes) |  | 0.032 * | 1.03 (0.49–2.28) | 0.948 |
  ≥ 360 | 82 |  |  |  |
  < 360 | 34 |  |  |  |
Blood loss (mL) |  | 0.550 | – | – |
  ≥ 200 | 81 |  |  |  |
  < 200 | 35 |  |  |  |
Transfusion |  | 0.612 | – | – |
 No | 100 |  |  |  |
 Yes | 16 |  |  |  |
T stage |  |  < 0.001*** | 1.92 (0.97–4.08) | 0.075 |
  < 3 | 57 |  |  |  |
  ≥ 3 | 59 |  |  |  |
N stage |  |  < 0.001*** | 1.99 (1.03–3.90) | 0.040* |
 0 | 69 |  |  |  |
 1 | 47 |  |  |  |
Tumor differentiation |  | 0.003** | 2.45 (1.29–4.83) | 0.006** |
 Well | 48 |  |  |  |
 Other | 68 |  |  |  |
PNI |  | 0.003** | 2.12 (1.09–4.04) | 0.027** |
  < 42 | 28 |  |  |  |
  ≥ 42 | 88 |  |  |  |
GPS |  | 0.065 | – | – |
 0 | 44 |  |  |  |
 1–2 | 72 |  |  |  |
CAR |  | 0.064 | – | – |
  < 1 | 65 |  |  |  |
  ≥ 1 | 51 |  |  |  |
NLR |  | 0.352 | – | – |
  < 2.55 | 85 |  |  |  |
  ≥ 2.55 | 31 |  |  |  |
PLR |  | 0.014* | 1.39 (0.69–2.92) | 0.357 |
  < 119 | 68 |  |  |  |
  ≥ 119 | 48 |  |  |  |
Postoperative complications (Clavien–Dindo grade ≥ IIIa) |  | 0.594 | – | – |
 Absent | 73 |  |  |  |
 Present | 43 |  |  |  |
Postoperative adjuvant chemotherapy |  | 0.518 | – | – |
 No | 36 |  |  |  |
 Yes | 80 |  |  |  |