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Table 2 Clinicopathological characteristics according to the PNI

From: A combined prediction model for biliary tract cancer using the prognostic nutritional index and pathological findings: a single-center retrospective study

Characteristic High PNI (≥ 42) (n = 88) Low PNI (< 42) (n = 28) P-value
Age (years), mean ± SD 73.3 ± 9.2 75.6 ± 10.9 0.271
Sex (male/female) 54/34 19/9 0.533
BMI (kg/m2), mean ± SD 22.6 ± 3.4 21.8 ± 4.4 0.336
CEA level (ng/mL), mean ± SD 6.35 ± 14.90 4.97 ± 4.26 0.631
CA19-9 level (U/mL), mean ± SD 1 072.7 ± 4 565.5 852.8 ± 2 528.4 0.809
Preoperative cholangitis (absent/present) 58/30 15/13 0.243
Comorbidities (absent/present) 25/63 9/19 0.707
Type of cancer (ICC/other) 23/65 7/21 0.905
Primary disease    0.130
 ICC 23 7  
 GBC 22 7  
 Distal cholangiocarcinoma 20 7  
 Ampullary carcinoma 16 1  
 Perihilar cholangiocarcinoma 7 6  
Surgical procedure
 Cholecystectomy 9 2 0.311
 Bile duct resection w/o liver resection 1 0  
 Minor hepatectomy 21 4  
 Major hepatectomy 22 13  
 Pancreaticoduodenectomy 34 8  
 Hepatopancreaticoduodenectomy 1 1  
Resection (R0–1/R2) 77/11 21/7 0.306
Operation time (minutes), mean ± SD 438 ± 149 514 ± 220 0.043*
Blood loss (mL), mean ± SD 717 ± 1 560 943 ± 1 341 0.491
Transfusion (no/yes) 79/9 21/7 0.062
T stage (≥ 3), n (%) 43 (48.9) 16 (57.1) 0.445
N stage (1), n (%) 30 (34.1) 17 (60.7) 0.013*
UICC stage (sixth edition) (I–II/III–IV) 56/32 12/16 0.053
Tumor differentiation (well/other) 37/51 11/17 0.796
Postoperative complications (Clavien–Dindo grade ≥ IIIa) (absent/present) 56/32 17/11 0.781
Postoperative adjuvant chemotherapy (no/yes) 28/60 8/20 0.745
  1. BMI body mass index, CA19-9 carbohydrate antigen 19-9, CEA carcinoembryonic antigen, GBC gallbladder carcinoma, ICC intrahepatic cholangiocarcinoma, PNI prognostic nutritional index, SD standard deviation, UICC Union for International Cancer Control, w/o without
  2. *P < 0.05; **P < 0.01