Table 2 Clinicopathological characteristics according to the PNI
Characteristic | High PNI (≥ 42) (n = 88) | Low PNI (< 42) (n = 28) | P-value |
|---|---|---|---|
Age (years), mean ± SD | 73.3 ± 9.2 | 75.6 ± 10.9 | 0.271 |
Sex (male/female) | 54/34 | 19/9 | 0.533 |
BMI (kg/m2), mean ± SD | 22.6 ± 3.4 | 21.8 ± 4.4 | 0.336 |
CEA level (ng/mL), mean ± SD | 6.35 ± 14.90 | 4.97 ± 4.26 | 0.631 |
CA19-9 level (U/mL), mean ± SD | 1 072.7 ± 4 565.5 | 852.8 ± 2 528.4 | 0.809 |
Preoperative cholangitis (absent/present) | 58/30 | 15/13 | 0.243 |
Comorbidities (absent/present) | 25/63 | 9/19 | 0.707 |
Type of cancer (ICC/other) | 23/65 | 7/21 | 0.905 |
Primary disease | Â | Â | 0.130 |
 ICC | 23 | 7 |  |
 GBC | 22 | 7 |  |
 Distal cholangiocarcinoma | 20 | 7 |  |
 Ampullary carcinoma | 16 | 1 |  |
 Perihilar cholangiocarcinoma | 7 | 6 |  |
Surgical procedure | |||
 Cholecystectomy | 9 | 2 | 0.311 |
 Bile duct resection w/o liver resection | 1 | 0 |  |
 Minor hepatectomy | 21 | 4 |  |
 Major hepatectomy | 22 | 13 |  |
 Pancreaticoduodenectomy | 34 | 8 |  |
 Hepatopancreaticoduodenectomy | 1 | 1 |  |
Resection (R0–1/R2) | 77/11 | 21/7 | 0.306 |
Operation time (minutes), mean ± SD | 438 ± 149 | 514 ± 220 | 0.043* |
Blood loss (mL), mean ± SD | 717 ± 1 560 | 943 ± 1 341 | 0.491 |
Transfusion (no/yes) | 79/9 | 21/7 | 0.062 |
T stage (≥ 3), n (%) | 43 (48.9) | 16 (57.1) | 0.445 |
N stage (1), n (%) | 30 (34.1) | 17 (60.7) | 0.013* |
UICC stage (sixth edition) (I–II/III–IV) | 56/32 | 12/16 | 0.053 |
Tumor differentiation (well/other) | 37/51 | 11/17 | 0.796 |
Postoperative complications (Clavien–Dindo grade ≥ IIIa) (absent/present) | 56/32 | 17/11 | 0.781 |
Postoperative adjuvant chemotherapy (no/yes) | 28/60 | 8/20 | 0.745 |