Table 3 Univariate and multivariate analyses of prognostic factors that influence overall survival of MANEC in gastric and ampullary
Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
No. of patients (%) | MOS (months) | P value | Hazard ratio (95%CI) | P value | |
Age (years) | |||||
< 60 | 16 | 24.0 | 0.297 | ||
≥ 60 | 16 | 42.0 | |||
Sex | |||||
Male | 26 | 28.0 | 0.539 | ||
Female | 6 | 24.0 | |||
Tumor location | |||||
Stomach | 25 | 25.0 | 0.644 | ||
Nonstomach | 7 | 28.0 | |||
Tumor size | |||||
≤ 3 cm | 14 | – | 0.001 | 3.006 [0.992, 9.107] | 0.052 |
> 3 cm | 18 | 15.0 | |||
T | |||||
T1/T2 | 7 | – | 0.006 | 6.089 [0.549, 67.571] | 0.141 |
T3/T4 | 25 | 24.0 | |||
Lymph node metastasis | |||||
No | 8 | – | 0.004 | 10.617 [1.409, 79.997] | 0.022 |
Yes | 24 | 18.0 | |||
TNM stage | |||||
I/II | 10 | – | 0.004 | 6.444 [1.477, 28.121] | 0.013 |
III/IV | 22 | 18.0 | |||
Grade of adenocarcinoma | |||||
Well/moderate differentiation | 20 | 42.0 | 0.003 | 3.876 [1.451, 10.357] | 0.007 |
Poor/signet ring cell/mucin | 12 | 12.0 | |||
Ki 67(%) | |||||
≤ 20 | 3 | 24.0 | 0.919 | ||
> 20 | 29 | 28.0 | |||
Cell type of NEC | |||||
Large cell | 11 | 25.0 | 0.956 | ||
Non-large cell | 21 | 28.0 | |||
Lymphatic invasion | |||||
Presence | 27 | 24.0 | 0.018 | – | 0.972 |
Absence | 5 | – | |||
Vascular invasion | |||||
Presence | 18 | 24.0 | 0.006 | 5.855 [1.719, 19.940] | 0.005 |
Absence | 14 | – | |||
Perineural invasion | |||||
Presence | 20 | 24.0 | 0.450 | ||
Absence | 12 | 30.0 | |||
Syn | |||||
(+) | 31 | 25.0 | 0.669 | ||
(−) | 1 | 28.0 | |||
CgA | |||||
(+) | 26 | 25.0 | 0.496 | ||
(−) | 6 | 28.0 | |||
CD56 | |||||
(+) | 14 | 30.0 | 0.006 | 0.265 [0.100, 0.705] | 0.008 |
(−) | 18 | 12.0 | |||
PCK | |||||
(+) | 18 | 25.0 | 0.736 | ||
(−) | 14 | 28.0 | |||
EMA | |||||
(+) | 11 | 25.0 | 0.657 | ||
(−) | 21 | 28.0 | |||
CK7 | |||||
(+) | 8 | 24.0 | 0.915 | ||
(−) | 24 | 25.0 | |||
Chemotherapy | |||||
Yes | 11 | 24.0 | 0.758 | ||
No | 21 | 28.0 | |||