Table 1 Comparison of baseline characteristics amongst patients with TPMT, with NUDT15 and without any mutations
TPMT mutated (N = 5) n (%)/ Median (IQR) | Wild Genotype (N = 102) n (%)/ Median (IQR) | P value | NUDT15 mutated (N = 13) n (%)/ Median (IQR) | Wild Genotype (N = 102) n (%)/ Median (IQR) | P value | |
|---|---|---|---|---|---|---|
Age (years) | 42 (16) | 35.5 (22) | 0.881 | 40 (19) | 35.5 (22) | 0.418 |
Male | 1 (20%) | 53 (51.9%) | 0.162 | 7 (53.8%) | 53 (51.9%) | 0.898 |
Smoker (past or present) | 0 | 16 (15.7%) | 1.00 | 2 (15.4%) | 16 (15.7%) | 1.000 |
Alcohol use (past or present) | 0 (100%) | 24 (23.5%) | 1.00 | 2 (15.4%) | 24 (23.5%) | 0.729 |
Body weight (kg) | 55 (18) | 55 (20) | 0.915 | 54 (8) | 55 (20) | 0.407 |
Comorbidities | 0 (0%) | 14 (13.7%) | 1.00 | 3 (23.1%) | 14 (13.7%) | 0.405 |
Recent Steroid Use (3 months) | 2 (40%) | 58 (56.9%) | 0.652 | 7 (53.8%) | 58 (56.9%) | 1.000 |
Current 5-Aminosalisylate use | 5 (100%) | 97 (95.1) | 1.000 | 12 (92.3%) | 97 (95.1) | 0.5214 |
Disease duration (months) | 48.0 (138) | 36 (41) | 0.949 | 36 (62) | 36 (41) | 0.168 |
Hemoglobin (g/dL) | 10.7 (4.81) | 11.2 (2.93) | 0.949 | 12.8 (2.35) | 11.2 (2.93) | 0.236 |
Total leucocyte count (× 106/L) | 9700 (4080) | 8950 (4400) | 0.348 | 9700 (4750) | 8950 (4400) | 0.477 |
Platelet count (× 106/L) | 354,000 (104,000) | 323,500 (183,250) | 0.327 | 292,000 (186,000) | 323,500 (183,250) | 0.516 |