Fig. 2

Time-dependent changes in pMayo score, FC, WBC, CR, ΔFC and ΔCRP during GMA. A time-dependent decline in the median pMayo score during GMA was observed in both the CR and non-CR groups. A time-dependent decrease in the median FC concentration during GMA was only observed in the CR group. A time-dependent change in the WBC count was not observed during GMA in either the CR or non-CR groups. A time-dependent decrease in the median CRP value during GMA was only observed in the CR group (a). Time-dependent decreases in the median ΔFC and median ΔCRP during GMA were only observed the CR group (b). The pMayo score, FC concentration, CRP value, ΔFC and ΔCRP at one week showed remarkable reductions from their values at entry (a, b). * and ** indicate statistically significant differences in comparison to baseline; p < 0.05 and p < 0.01, respectively. pMayo: partial Mayo score, FC: fecal calprotectin, WBC: white blood cell, CRP: C reactive protein, ΔFC: the reduction rate of FC, ΔCRP: the reduction rate of CRP, GMA: granulocyte and monocyte adsorptive apheresis, CR: clinical remission