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Table 1 Baseline demographic and clinicopathological characteristics of patients with SRC vs. non-SRC

From: Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder

Parameters SRC (n = 377) Non-SRC (n = 22,404) P Value
Age, years    
 < 60 83 (22.0%) 6954 (31.0%)  < 0.001
 ≥ 60 294 (78.0%) 15,450 (69.0%)  
Sex    
Male 88 (23.3%) 6625 (29.6%) 0.009
Female 289 (76.7%) 15,779 (70.4%)  
Race    
White 291 (77.2%) 17,781 (79.4%) 0.535
Black 44 (11.7%) 2264 (10.1%)  
Other 42 (11.1%) 2359 (10.5%)  
Clinical T-stage    
T1–T2 87 (23.1%) 4750 (21.2%)  < 0.001
T3–T4 121 (32.1%) 5248 (23.4%)  
Unknown 169 (44.8%) 12,406 (55.4%)  
Lymph node metastasis    
No 115 (30.5%) 6802 (30.4%)  < 0.001
Yes 91 (24.1%) 3158 (14.1%)  
Unknown 171 (45.4%) 12,444 (55.5%)  
Distant metastasis    
No 133 (35.3%) 6693 (29.9%)  < 0.001
Yes 93 (24.7%) 4445 (19.8%)  
Unknown 151 (40.1%) 11,266 (50.3%)  
AJCC stage    
I–II 118 (31.3%) 5811 (25.9%)  < 0.001
III–IV 105 (27.9%) 5054 (22.6%)  
Unknown 154 (40.8%) 11,539 (51.5%)  
Histologic grade    
Well-moderate 23 (6.1%) 8629 (38.5%)  < 0.001
Poor-undifferentiated 269 (71.4%) 6588 (29.4%)  
Unknown 85 (22.5%) 7187 (32.1%)  
Surgery    
Yes 246 (65.3%) 7138 (31.9%)  < 0.001
No 66 (17.5%) 3556 (15.9%)  
Unknown 65 (17.2%) 11,710 (52.3%)  
Radiotherapy    
Yes 52 (13.8%) 2354 (10.5%) 0.04
No 325 (86.2%) 20,050 (89.5%)  
Chemotherapy    
Yes 125 (33.2%) 6006 (26.8%) 0.006
No 252 (66.8%) 16,398 (73.2%)  
Year of diagnosis    
1975–2009 249 (66.0%) 15,676 (70.0%) 0.100
2010–2016 128 (34.0%) 6728 (30.0%)  
Marital status    
Married 183 (48.5%) 11,854 (52.9%) 0.092
Unmarried 194 (51.5%) 10,550 (47.1%)  
  1. SRC signet ring cell carcinoma, AJCC American Joint Committee on Cancer