Fig. 5

Hippocampal GFAP expression is more pronounced in cerulein-treated mice without XPro1595 administration. CA1 hippocampal GFAP expression was semi-quantitated 7 days following induction of pancreatitis in mice. Non-pancreatitis mouse groups, independent of vehicle or XPro1595 treatment, did not display reactive astrogliosis (a, c) (n = 3–4). In contrast, the vehicle-treated pancreatitis tissue (b) had numerous reactive astrocytes and when quantitated displayed a tendency for increased GFAP expression (n = 4), compared to the non-pancreatitis groups, but was not statistically significantly different (e). XPro1595 treated pancreatitis mice prevented the induction of reactive astrocytes (d) (n = 4). NC non-cerulein, C cerulein, V vehicle, XP XPro1595, scalebar = 100 µm