Fig. 3

Selective inhibition of solTNF in mice with acute pancreatitis prevents pancreatic tissue degradation at 7 days after induction. Photomicrographs illustrate H&E stained pancreatic sections from mice with acute pancreatitis (cerulein treated) with either vehicle—a (n = 4) or XPro1595-treatment b (n = 4), where quantification shows vehicle-treated pancreatitis mice have significant deterioration of tissue integrity (c), compared to pancreatitis mice treated with XPro1595 (n = 4), or non-pancreatitis mice (n = 3–4). In accordance, the vehicle-treated pancreatitis mice also display an exacerbated level of pancreatic acinar cell atrophy (d) that is not observed in the XPro1595 treated pancreatitis group (e, f). A week after induction of pancreatitis the intralobular ducts in the vehicle-treated group appeared to be invaded by groups of acini spreading apart (g), although this was less prominent in the XPro1595-treated group (h, i). NC non-cerulein, C cerulein, V vehicle, XP XPro1595, *p < 0.05, **p < 0.01, ***p < 0.001, scale bar in a and b = 500 µm, scalebar in d and e = 25 µm, scalebar in g and h = 500 µm