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Table 2 Patients’ characteristics according to their anemia history (N = 1394)

From: The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study

 

Group A

No anemia

Group B

Episodic anemia

Group C

Recurrent/persistent anemia

P

Number (%)

707 (50.7)

413 (29.6)

274 (19.7)

 

Males/females (%)

432/275 (61.1/38.9)

208/205 (50.4/49.6)

119/155 (43.4/56.6)

 < 0.0001

CD/UC (%)

412/ 295 (58.3/41.7)

236/177 (57.1/42.9)

186/88 (67.9/32.1)

0.0089

Median IBD durationa (years, range)

5 (2–11)

1 (0–4)

2 (0–8)

 < 0.0001

Median diagnosis age (years, range)

35 (24–46)

32 (23–45.5)

30 (21–46)

 < 0.0001

Active smokers (%)

238 (33.7)

121 (29.3)

83 (30.3)

0.2356

Ex-smokers (%)

205 (29)

96 (23.2)

64 (23.3)

0.0435

Never smoked (%)

264 (37.3)

195 (47.2)

127 (46.4)

0.0008

Median BMI (range)

25.2 (22.5–28.6)

24.2 (21.3–27.25)

23.5 (20.7–27.0)

 < 0.0001

Montreal classification for UC

Proctitis (E1, %)

53 (18)

7 (3.9)

3 (3.4)

 < 0.0001

Left sided colitis (E2, %)

129 (43.7)

75 (42.4)

33 (37.5)

0.5834

Extensive colitis (E3, %)

113 (38.3)

95 (53.7)

52 (59.1)

0.0002

Montreal classification for CD

Inflammatory (B1, %)

272 (66)

154 (65.2)

89 (47.8))

 < 0.0001

Stricturing (B2, %)

84 (20.4)

45 (19.1)

61 (32.8)

0.6111

Penetrating (B3, %)

56 (13.6)

36 (15.2)

36 (19.4)

0.6050

Perianal (p, %)

80 (19.4)

42 (17.8)

42 (22.5)

0.4901

Ileum (L1, N, %)

209 (50.7)

97 (41.1)

70 (37.6)

0.0037

Colon (L2, N, %)

35 (8.5)

23 (9.7)

20 (10.8)

0.6575

Ileocolonic (L3, N, %)

168 (40.8)

116 (49.2)

96 (51.6)

0.0191

Upper GI (L4, N, %)

46 (11.2)

41 (17.4)

27 (14.5)

0.0766

Disease activity—clinically judged

176 (24.9)

238 (57.6)

145 (52.9)

 < 0.0001

EIMs (%)

199 (28.1)

138 (33.4)

131 (47.8)

 < 0.0001

Anti-TNFs (N, %)

261 (36.9)

242 (58.6)

188 (68.6)

 < 0.0001

Immunomodulators (N, %)

225 (31.8)

175 (42.4)

129 (47.1)

 < 0.0001

Other biologics (N, %)

82 (11.6)

90 (21.8)

58 (21.2)

0.0624

IBD-related surgery (N, %)

61 (8.6)

51 (12.3)

64 (23.4)

 < 0.0001

  1. Group A never anemic patients, Group B episodically anemic patients, Group C recurrently/persistently anemic patients
  2. UC, Ulcerative Colitis; CD, Crohn’s Disease; BMI, Body Mass Index; IBD, Inflammatory Bowel Disease; GI, Gastrointestinal; EIMs, Exta-intestinal Manifestations; Anti-TNFs, Anti-Tumor Necrosis Factors
  3. aAt first presentation of anemia for anemic patients or at entry for non-anemic patients
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BMC Gastroenterology

ISSN: 1471-230X

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